Central Clinical School, Faculty of Medicine and Health, University of Sydney, NSW, Australia.
Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
J Vestib Res. 2020;30(6):345-352. doi: 10.3233/VES-200022.
Healthy controls exhibit spontaneous and positional nystagmus which needs to be distinguished from pathological nystagmus.
Define nystagmus characteristics of healthy controls using portable video-oculography.
One-hundred and one asymptomatic community-dwelling adults were prospectively recruited. Participants answered questions regarding their audio-vestibular and headache history and were sub-categorized into migraine/non-migraine groups. Portable video-oculography was conducted in the upright, supine, left- and right-lateral positions, using miniature take-home video glasses.
Upright position spontaneous nystagmus was found in 30.7% of subjects (slow-phase velocity (SPV)), mean 1.1±2.2 degrees per second (°/s) (range 0.0 - 9.3). Upright position spontaneous nystagmus was horizontal, up-beating or down-beating in 16.7, 7.9 and 5.9% of subjects. Nystagmus in at least one lying position was found in 70.3% of subjects with 56.4% showing nystagmus while supine, and 63.4% in at least one lateral position. While supine, 20.8% of subjects showed up-beating nystagmus, 8.9% showed down-beating, and 26.7% had horizontal nystagmus. In the lateral positions combined, 37.1% displayed horizontal nystagmus on at least one side, while 6.4% showed up-beating, 6.4% showed down-beating. Mean nystagmus SPVs in the supine, right and left lateral positions were 2.2±2.8, 2.7±3.4, and 2.1±3.2°/s. No significant difference was found between migraine and non-migraine groups for nystagmus SPVs, prevalence, vertical vs horizontal fast-phase, or low- vs high-velocity nystagmus (<5 vs > 5°/s).
Healthy controls without a history of spontaneous vertigo show low velocity spontaneous and positional nystagmus, highlighting the importance of interictal nystagmus measures when assessing the acutely symptomatic patient.
健康对照者会出现自发性和位置性眼球震颤，需要将其与病理性眼球震颤区分开来。
使用便携式视频眼震描记术定义健康对照者的眼球震颤特征。
前瞻性招募了 101 名无症状的社区居住成年人。参与者回答了有关其听觉-前庭和头痛病史的问题，并被分为偏头痛/非偏头痛组。使用微型带回家的视频眼镜，在直立、仰卧、左侧和右侧位置进行便携式视频眼震描记术。
在 30.7%的受试者（慢相速度（SPV））中发现直立位自发性眼球震颤，平均 1.1±2.2 度/秒（°/s）（范围 0.0-9.3）。在 16.7%、7.9%和 5.9%的受试者中，直立位自发性眼球震颤为水平、上跳或下跳。70.3%的受试者在至少一个卧位时出现眼球震颤，其中 56.4%在仰卧位时出现眼球震颤，63.4%在至少一个侧卧位时出现眼球震颤。仰卧位时，20.8%的受试者出现上跳性眼球震颤，8.9%出现下跳性眼球震颤，26.7%出现水平性眼球震颤。在双侧卧位中，37.1%的受试者在至少一侧出现水平性眼球震颤，6.4%的受试者出现上跳性眼球震颤，6.4%的受试者出现下跳性眼球震颤。仰卧位、右侧和左侧卧位的平均眼球震颤 SPV 分别为 2.2±2.8、2.7±3.4 和 2.1±3.2°/s。偏头痛和非偏头痛组之间的眼球震颤 SPV、患病率、垂直快相与水平快相或低速度与高速度眼球震颤（<5 与>5°/s）无显著差异。
无自发性眩晕病史的健康对照者会出现低速度自发性和位置性眼球震颤，这突出了在评估急性症状患者时间歇性眼球震颤测量的重要性。
