Department of Thoracic and Cardiovascular Surgery, College of Medicine, Chungbuk National University and Chungbuk National University Hospital, 1 Chungdae-Ro, Seowon-Gu, Cheongju, Chungbuk, 28644, Korea.
Office of Public Healthcare Service, Chungbuk National University Hospital, Chungbuk, Korea.
Ther Adv Respir Dis. 2020 Jan-Dec;14:1753466620977408. doi: 10.1177/1753466620977408.
The factors that trigger spontaneous pneumothorax have not been sufficiently evaluated. The purpose of this study is to analyze the relationship between the development of spontaneous pneumothorax and meteorological parameters, including air pollutants.
This is a retrospective study using the medical records of 379 patients who were admitted for spontaneous pneumothorax (SP) over a period of 4 years. Meteorological and air pollution data were obtained from the National Meteorological Office and the Ministry of Environment. We employed a case-crossover design to evaluate the short-term association between SP and meteorological factors including air pollutants. Conditional logistic regression was used to analyze bi-directional matched data.
Increase of relative humidity (RH) and of carbon monoxide (CO) were associated with the risk of pneumothorax, with odds ratio (OR) for RH = 1.18 (1.02-1.36), CO = 1.23 (1.02-1.48). Moreover, as air pressure (AP) decreased, risk of pneumothorax increased, with OR = 1.30 (1.05-1.59) but others did not. In the stratified analysis, the effect of RH was positive in ex-smokers (OR = 3.31) and non-smokers (OR = 1.32), but negative in current smokers (OR = 0.72). The effect of AP was significant in younger patients (OR = 1.33), males (OR = 1.40), and non-smokers (OR = 1.36). CO was related only with non-smokers (OR = 1.35).
The triggering factors for spontaneous pneumothorax were relative humidity, carbon monoxide, and air pressure. The effect of the trigger was prominent in patients who were younger (<45 years), non- or ex-smokers, and male.
自发性气胸的诱发因素尚未得到充分评估。本研究旨在分析自发性气胸的发展与气象参数（包括空气污染物）之间的关系。
这是一项回顾性研究，使用了 4 年内因自发性气胸（SP）住院的 379 名患者的病历。气象和空气污染数据来自国家气象局和环境部。我们采用病例交叉设计来评估 SP 与气象因素（包括空气污染物）之间的短期关联。使用条件逻辑回归分析双向匹配数据。
相对湿度（RH）和一氧化碳（CO）的增加与气胸风险相关，RH 的比值比（OR）为 1.18（1.02-1.36），CO 的 OR 为 1.23（1.02-1.48）。此外，随着气压（AP）下降，气胸的风险增加，OR 为 1.30（1.05-1.59），但其他因素没有。在分层分析中，RH 的影响在戒烟者（OR=3.31）和不吸烟者（OR=1.32）中为正，但在吸烟者（OR=0.72）中为负。AP 的影响在年轻患者（OR=1.33）、男性（OR=1.40）和不吸烟者（OR=1.36）中显著。CO 仅与不吸烟者（OR=1.35）相关。
自发性气胸的诱发因素是相对湿度、一氧化碳和气压。触发因素的影响在年龄较小（<45 岁）、不吸烟或已戒烟、以及男性患者中更为明显。
