Division of Plastic Surgery, Mayo Clinic, Jacksonville, FL, U.S.A.
Section of Plastic Surgery, Yale University, New Haven, CT, U.S.A.
Anticancer Res. 2020 Dec;40(12):6609-6612. doi: 10.21873/anticanres.14685.
BACKGROUND/AIM: Treatment of gynecologic cancers may lead to the development of lower limb lymphedema. As the course of lymphedema is chronic and progressive, early diagnosis plays a significant role in decreasing morbidity. Therefore, risk assessment is of utmost importance. In this study, we aimed to investigate the impact of age on lymphedema development after treatment for gynecologic cancers.
The search of 3 databases (PubMed, Scopus, and Cochrane) revealed 7 relevant articles, which reported either odds ratios or hazard ratios as an outcome measure.
A positive relationship between younger age and lower limb lymphedema was shown by 3 articles, while 2 noted increased incidence with older age. The remaining articles reported no significant relationship.
Younger age is a risk factor for gynecologic cancer-related lymphedema. However, as individual studies have not included all types of gynecologic cancers, results may not be generalizable.
背景/目的：妇科癌症的治疗可能导致下肢淋巴水肿的发生。由于淋巴水肿的病程是慢性且进行性的，早期诊断对于降低发病率起着重要作用。因此，风险评估至关重要。本研究旨在探讨年龄对妇科癌症治疗后淋巴水肿发展的影响。
对 3 个数据库（PubMed、Scopus 和 Cochrane）进行检索，共发现 7 篇相关文章，这些文章均以比值比或风险比作为结局指标进行报告。
有 3 篇文章表明，年龄较小与下肢淋巴水肿呈正相关，而 2 篇文章则指出年龄较大与发病率增加有关。其余文章则未报告出有统计学意义的相关性。
年轻是妇科癌症相关淋巴水肿的一个危险因素。然而，由于个别研究并未包含所有类型的妇科癌症，因此结果可能不具有普遍性。
