Department of Gynecology, Kuopio University Hospital, Kuopio, Finland
Department of Gynecology, Kuopio University Hospital, Kuopio, Finland.
Anticancer Res. 2020 Dec;40(12):6923-6931. doi: 10.21873/anticanres.14716. Epub 2020 Dec 7.
BACKGROUND/AIM: Examine features of blood and lymphatic vessels in ovarian tumors and their significance to prognosis of ovarian cancer.
A total of 139 women with epithelial ovarian tumors were included: 86 malignant, 17 borderline and 36 benign. Density, percentage, mean size and number of blood microvessels in tumors were measured by immunohistochemistry with antibodies against CD34 and CD105. Lymphatic vessel density was assayed using the D2-40 antibody against podoplanin.
Angiogenesis was most profuse in malignant tumors. Small size of lymph vessels predicted 26% shorter 5-year survival of ovarian cancer patients. Further, high percentage of lymphatic vessels in tumors was associated with lymph node metastasis, and high density with cancer recurrence. Lower number of microvessels, as assessed by CD34 staining, predicted shorter progression-free survival. Additionally, the large size of microvessels assessed by CD34 and the high number of vessels assessed by CD105 were related to residual tumor >1 cm at primary surgery and also, large vessel size was associated with stage III, as assessed by CD105 staining.
CD34 and CD105 define different characteristics of microvessels. Parameters of lymph vessels may predict the prognosis of ovarian cancer.
背景/目的：研究卵巢肿瘤中血液和淋巴管的特征及其对卵巢癌预后的意义。
共纳入 139 名上皮性卵巢肿瘤患者：86 例恶性，17 例交界性和 36 例良性。采用针对 CD34 和 CD105 的抗体通过免疫组化测量肿瘤中微血管的密度、百分比、平均大小和数量。使用针对 podoplanin 的 D2-40 抗体检测淋巴管密度。
恶性肿瘤中血管生成最为丰富。小淋巴管的大小预示着卵巢癌患者 5 年生存率缩短 26%。此外，肿瘤中高比例的淋巴管与淋巴结转移有关，高密度与癌症复发有关。通过 CD34 染色评估的微血管数量较低，预示着无进展生存期缩短。此外，通过 CD34 评估的大微血管大小和通过 CD105 评估的大血管数量与原发性手术中残留肿瘤 >1cm 有关，并且大血管大小与 CD105 染色评估的 III 期有关。
CD34 和 CD105 定义了微血管的不同特征。淋巴管的参数可能预测卵巢癌的预后。
