重新讨论传统危险因素在年轻人口腔鳞状细胞癌中的作用。
Rediscussing the Role of Traditional Risk Factors in Young Adults With Oral Squamous Cell Carcinoma.
机构信息
Department of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Department of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
出版信息
Anticancer Res. 2020 Dec;40(12):6987-6995. doi: 10.21873/anticanres.14723.
BACKGROUND/AIM: The current literature conjectures that oral squamous cell carcinoma (OSCC) in younger patients is an entirely separate entity with a different risk profile. We aimed to uncover the potential risk factors of OSCC and evaluated the long-term outcome in such patients.
PATIENTS AND METHODS
This hospital-based case-control study included 40 patients with OSCC and 40 controls under the age of 46 years. Survival was analyzed via Kaplan-Meier estimates, including a follow-up of up to 24.3 years.
RESULTS
The patients with OSCC were prone to smoking and drinking heavily and even suffered secondary organ damage to the lungs and the liver at this young age. Early diagnosed as well as surgically treated patients had superior 5-year recurrence-free and overall survival.
CONCLUSION
Young patients with OSCC were found to have a traditional risk profile. Secondary organ damage to the liver and the lungs might be considered as a risk indicator. The meticulous screening of every age group with this risk profile is key to early diagnosis and acceptable treatment results.
背景/目的：目前的文献推测，年轻患者的口腔鳞状细胞癌（OSCC）是一种完全不同的实体，具有不同的风险特征。我们旨在揭示 OSCC 的潜在风险因素，并评估此类患者的长期预后。
患者和方法
这项基于医院的病例对照研究纳入了 40 名年龄在 46 岁以下的 OSCC 患者和 40 名对照者。通过 Kaplan-Meier 估计进行生存分析，随访时间长达 24.3 年。
结果
OSCC 患者有吸烟和酗酒的倾向，甚至在这么年轻的时候就已经遭受了肺部和肝脏的继发性器官损伤。早期诊断和手术治疗的患者，其 5 年无复发生存率和总生存率更高。
结论
年轻的 OSCC 患者具有传统的风险特征。肝脏和肺部的继发性器官损伤可能被视为一个风险指标。对具有这种风险特征的每个年龄段进行细致的筛查是实现早期诊断和可接受治疗结果的关键。
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