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SINBAD 和德克萨斯大学溃疡评分系统的溃疡结局独立观察性分析。

Independent Observational Analysis of Ulcer Outcomes for SINBAD and University of Texas Ulcer Scoring Systems.

机构信息

Strathmore Diabetes Centre, Ninewells Hospital, Dundee, U.K.

出版信息

Diabetes Care. 2021 Feb;44(2):326-331. doi: 10.2337/dc20-1817. Epub 2020 Dec 7.

Abstract

OBJECTIVE

The aim of this study was to compare the University of Texas (UT) and Site, Ischemia, Neuropathy, Bacterial Infection, and Depth (SINBAD) foot ulcer scores in predicting ulcer outcome within a routine diabetes foot clinic.

RESEARCH DESIGN AND METHODS

From 2006 to 2018, data were collected from all patients attending an outpatient diabetes foot clinic with an active ulcer not healed within 4 weeks. UT and SINBAD were compared in predicting ulcer outcome. A unified numerical score for UT was constructed and compared with UT grade (depth) and stage scores. Outcomes included death, a healed ulcer, or a nonhealed ulcer, which included major or minor amputation and nonhealing chronic ulcers.

RESULTS

Outcomes were available from 1,645 ulcer outcomes in 1,068 patients (mean [SD] age 65.4 [4] years, 72% male), of which 1,108 (67%) healed. With exclusion of death as an adverse outcome, the c-statistic (area under operator curve) was 0.67 (95% CI 0.65-0.71) for UT grade/depth and 0.64 (0.61-0.67) for UT stage. The new unified UT score had an improved c-statistic of 0.71 (0.68-0.74). The c-statistic was 0.72 (0.69-0.75) for SINBAD. There was a stepwise decrease in the proportion of ulcers healed for each increased score on ulcer grading for both grading schemes.

CONCLUSIONS

This large and independent observational comparison, in a real-world clinical setting, demonstrated that the UT and SINBAD diabetes foot ulcer grading schemes had similar prognostic ability for predicting foot ulcer outcomes. We have devised and validated a unified numerical scoring system for UT.

摘要

目的

本研究旨在比较德克萨斯大学(UT)和部位、缺血、神经病变、细菌感染和深度(SINBAD)足部溃疡评分在常规糖尿病足诊所中预测溃疡结局的能力。

研究设计和方法

2006 年至 2018 年,从所有在门诊糖尿病足诊所就诊的患者中收集数据,这些患者有活跃的溃疡,在 4 周内未愈合。比较 UT 和 SINBAD 预测溃疡结局的能力。构建了 UT 的统一数字评分,并将其与 UT 分级(深度)和分期评分进行比较。结局包括死亡、溃疡愈合和未愈合溃疡,包括大或小截肢和未愈合的慢性溃疡。

结果

在 1068 名患者的 1645 例溃疡结局中,有结局数据(平均[标准差]年龄 65.4[4]岁,72%为男性),其中 1108 例(67%)愈合。排除死亡作为不良结局,UT 分级/深度的 C 统计量(操作曲线下面积)为 0.67(95%置信区间 0.65-0.71),UT 分期为 0.64(0.61-0.67)。新的统一 UT 评分的 C 统计量提高到 0.71(0.68-0.74)。SINBAD 的 C 统计量为 0.72(0.69-0.75)。对于两种分级方案,溃疡分级评分每增加一分,愈合溃疡的比例呈阶梯式下降。

结论

在真实临床环境中,这项大型且独立的观察性比较表明,UT 和 SINBAD 糖尿病足溃疡分级方案在预测足溃疡结局方面具有相似的预后能力。我们已经设计并验证了 UT 的统一数字评分系统。

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