喉鳞状细胞乳头状瘤患者发生高级别发育异常和癌的危险因素：大型回顾性队列研究
Risk factors for the development of high-grade dysplasia and carcinoma in patients with laryngeal squamous cell papillomas: Large retrospective cohort study.
作者信息
Gluvajić Daša, Hošnjak Lea, Stegel Vida, Novaković Srdjan, Gale Nina, Poljak Mario, Boltežar Irena Hočevar
机构信息
Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Centre, Ljubljana, Slovenia.
Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Slovenia.
出版信息
Head Neck. 2020 Dec 1. doi: 10.1002/hed.26560.
BACKGROUND
The incidence and risk factors for the development of high-grade dysplasia (HG-D) and laryngeal squamous cell carcinoma (LSCC) were assessed in patients with laryngeal squamous cell papillomas (LSP).
METHODS
Clinical data, human papillomaviruses (HPV) typing, HPV E6/E7 mRNA in situ hybridization, and sequencing of host genes in LSP biopsies of 163 patients were analyzed.
RESULTS
Progression to HG-D and LSCC was identified in 21.5% and 4.3% of LSP patients, respectively. A more advanced age at LSP onset and lack of HPV infection were detected as risk factors for the development of HG-D and LSCC (P < .05). The identification of HG-D was associated with its progression to LSCC (P < .05). Host gene mutations were identified in 3 of 7 patients with LSCC.
CONCLUSIONS
The histological monitoring of LSP and HPV typing are necessary for early detection of epithelial changes. Further research is needed to elucidate the role of host gene mutations in LSCC transformation.
背景
评估喉鳞状细胞乳头状瘤（LSP）患者发生高级别发育异常（HG-D）和喉鳞状细胞癌（LSCC）的发生率及危险因素。
方法
分析163例LSP活检患者的临床资料、人乳头瘤病毒（HPV）分型、HPV E6/E7 mRNA原位杂交及宿主基因测序情况。
结果
分别有21.5%和4.3%的LSP患者进展为HG-D和LSCC。LSP发病时年龄较大及无HPV感染被检测为HG-D和LSCC发生的危险因素（P < 0.05）。HG-D的识别与进展为LSCC相关（P < 0.05）。7例LSCC患者中有3例鉴定出宿主基因突变。
结论
LSP的组织学监测和HPV分型对于上皮变化的早期检测是必要的。需要进一步研究以阐明宿主基因突变在LSCC转化中的作用。
Zotero 插件