布拉氏酵母菌在实验性贾第虫病中的治疗选择。
Saccharomyces boulardii as therapeutic alternative in experimental giardiasis.
机构信息
Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Department of Basic Life Sciences, Universidade Federal de Juiz de Fora - Campus Governador Valadares, Valadares, MG, Brazil.
出版信息
J Appl Microbiol. 2021 Jul;131(1):460-469. doi: 10.1111/jam.14941. Epub 2020 Dec 9.
AIMS
The objective of this study was to evaluate the effect of treatment with the probiotic Saccharomyces boulardii with or without metronidazole in experimental giardiasis.
METHODS AND RESULTS
The effect of treatment with S. boulardii with or without metronidazole on the intestinal mucosa, the antioxidant defence system and the parasitic load was determined in experimental giardiasis. Eight groups of animals with infection and/or treatment with the probiotic and/or drugs for 1 week after infection with Giardia lamblia were used. A reduction of approximately 90% in the parasitic load was observed in all the treated groups. Saccharomyces boulardii attenuated the damage caused by infection in the intestinal mucosa preserving its architecture and inhibiting the oxidative stress induced by parasite and metronidazole.
CONCLUSIONS
Saccharomyces boulardii was effective alone or in combination with metronidazole in resolving already established G. lamblia infection.
SIGNIFICANCE AND IMPACT OF THE STUDY
These results suggest the use of S. boulardii as an alternative treatment for giardiasis mainly in cases of resistance or intolerance to conventional treatment.
目的
本研究旨在评估布拉氏酵母菌与或不与甲硝唑联合治疗实验性贾第虫病的效果。
方法和结果
本研究采用 8 组感染动物和/或用益生菌和/或药物治疗 1 周，确定布拉氏酵母菌与或不与甲硝唑联合治疗对实验性贾第虫病的肠黏膜、抗氧化防御系统和寄生虫负荷的影响。所有治疗组的寄生虫负荷均减少了约 90%。布拉氏酵母菌减轻了感染引起的肠黏膜损伤，保持其结构完整，并抑制寄生虫和甲硝唑诱导的氧化应激。
结论
布拉氏酵母菌单独或与甲硝唑联合治疗已确立的蓝氏贾第鞭毛虫感染有效。
研究的意义和影响
这些结果提示使用布拉氏酵母菌作为贾第虫病的替代治疗方法，主要适用于对常规治疗有耐药性或不耐受的情况。
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