Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2020 Dec 7;35(47):e407. doi: 10.3346/jkms.2020.35.e407.
Previous exposure to antimicrobials is a major risk factor for infection (CDI). Antibiotic prescription and toxin assay records of patients admitted to a tertiary hospital in Korea from 2009 to 2013 were collected to investigate the association between antibiotic consumption and CDI incidence. A Spearman's correlation analysis between CDI incidence (positive result of toxin assay/10,000 admissions) and antibiotic consumption (defined daily dose/1,000 patient-days) was performed on a monthly basis. Using the matched month approach, we found a significant correlation between CDI rate and moxifloxacin consumption (Spearman's = 0.351, < 0.001). Furthermore, using the one-month delay approach, we found that the consumption of clindamycin (Spearman's = 0.272, = 0.037) and moxifloxacin (Spearman's = 0.297, = 0.022) was significantly correlated with CDI incidence. Extended-spectrum cephalosporins did not have any effect on CDI incidence.
先前接触抗生素是感染（CDI）的主要危险因素。收集了韩国一家三级医院 2009 年至 2013 年住院患者的抗生素处方和毒素检测记录，以调查抗生素使用与 CDI 发生率之间的关系。每月对 CDI 发生率（毒素检测阳性结果/10000 人次）和抗生素使用量（定义为每日剂量/1000 患者日）进行 Spearman 相关性分析。使用匹配月份的方法，我们发现 CDI 发生率与莫西沙星使用量之间存在显著相关性（Spearman's = 0.351， < 0.001）。此外，使用一个月延迟法，我们发现克林霉素（Spearman's = 0.272， < 0.001）和莫西沙星（Spearman's = 0.297， < 0.001）的使用与 CDI 发生率显著相关。而头孢菌素类药物对 CDI 发生率没有影响。
