Ben Mabrouk A, Ben Brahim H, Kooli I, Marrakchi W, Aouam A, Loussaief C, Toumi A, Chakroun M
University Hospital Fattouma Bourguiba of Monastir, Infectious Diseases Department, 5019 Monastir, Tunisie.
University Hospital Fattouma Bourguiba of Monastir, Infectious Diseases Department, 5019 Monastir, Tunisie.
Ann Pharm Fr. 2021 May;79(3):244-254. doi: 10.1016/j.pharma.2020.10.010. Epub 2020 Oct 22.
Tigecycline is a relatively new antibiotic that have very limited valid indications. When no other alternative is available, this drug is widely used off label with promising results. The objective of this study is to summarize the different off label uses of tigecycline so that we can decide when and how to prescribe it in the absence of guidelines.
This study a revue of the literature collecting all the articles concerning the off label uses of tigecycline.
Tigecycline was widely prescribed, off label, to treat infections with controversial results. Randomised clinical trials were conducted to evaluate its use to treat pneumonia. The results for this indication have a respectable level of evidence. For the other indications, the data collected was insufficient to support tigecycline prescription. In fact, different protocols were used which makes it hard to evaluate the efficacy and to conclude to the best treatment regimen. A tendency to prescribe high doses of the molecule was noted in different studies. When prescribed off label, tigecycline prescriptions were associated with a higher mortality and incidence of side effects.
The tigecycline remains a valid option for the treatment of infections dues to multi-resistant bacteria especially when other alternatives are scarce or in cases of renal failure.
替加环素是一种相对较新的抗生素，其有效适应证非常有限。当没有其他替代药物时，这种药物被广泛用于非适应证用药，且取得了不错的效果。本研究的目的是总结替加环素不同的非适应证用药情况，以便在没有指南的情况下，我们能够决定何时以及如何开具该药物的处方。
本研究对文献进行了综述，收集了所有关于替加环素非适应证用药的文章。
替加环素被广泛用于非适应证治疗感染，但结果存在争议。进行了随机临床试验以评估其治疗肺炎的用途。该适应证的结果有一定程度的证据支持。对于其他适应证，收集的数据不足以支持替加环素的处方。事实上，使用了不同的方案，这使得难以评估疗效并得出最佳治疗方案。在不同研究中发现有开具高剂量该药物的倾向。当进行非适应证用药时，替加环素的处方与更高的死亡率和副作用发生率相关。
替加环素仍然是治疗多重耐药菌感染的有效选择，特别是在其他替代药物稀缺或肾衰竭的情况下。
