COVID-19 Research Center, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, The First School of Clinical Medicine, Southern Medical University, Nanjing 210002, Jiangsu, China.
Department of Laboratory Medicine, Nanjing Red Cross Blood Center, Nanjing 210003, Jiangsu, China.
Aging (Albany NY). 2020 Dec 3;12(23):23427-23435. doi: 10.18632/aging.202193.
The characteristics of COVID-19 patients with autoimmune rheumatic diseases (AIRD) have rarely been reported. Patients with AIRD have suppressed immune defense function, which may increase their susceptibility to COVID-19. However, the immunosuppressive agents AIRD patients routinely used may be beneficial for protecting the cytokine storm caused by SARS-CoV-2. In this retrospective study, we included all confirmed cases in Huoshenshan Hospital from February 4 to April 9. Data were extracted from electronic medical records and were analyzed for clinical and laboratory features using SPSS (version 25.0). Of 3059 patients, 21 had the comorbidities with systematic lupus erythematosus (SLE) and/or rheumatoid arthritis (RA), including 5 with SLE, 15 with RA, and 1 with Rhupus. The proportion was 57.1% for severe cases, 61.9% for either severe or critical cases, and 4.8% for critical cases. The main manifestations, ARDS and ICU admission rate, as well as the mortality and length of hospital stay of COVID-19 in AIRD patients were similar to COVID-19 patients in the general population. Our preliminary experience shows that patients with AIRD tend to have a higher risk of SARS-CoV-2 infection, and may be at risk for a severe but less likely critical disease course. Further investigation is needed to understand the immunological features of these diseases.
COVID-19 合并自身免疫性风湿病（AIRD）患者的特征鲜有报道。患有 AIDR 的患者免疫防御功能受到抑制，这可能使他们更容易感染 COVID-19。然而，AIDR 患者常规使用的免疫抑制剂可能有利于保护由 SARS-CoV-2 引起的细胞因子风暴。在这项回顾性研究中，我们纳入了 2 月 4 日至 4 月 9 日在火神山医院确诊的所有病例。从电子病历中提取数据，并使用 SPSS（版本 25.0）分析临床和实验室特征。在 3059 例患者中，有 21 例患有系统性红斑狼疮（SLE）和/或类风湿关节炎（RA），包括 5 例 SLE、15 例 RA 和 1 例 Rhupus。严重病例比例为 57.1%，重症或危重症病例比例为 61.9%，危重症病例比例为 4.8%。COVID-19 在 AIDR 患者中的主要表现、ARDS 和 ICU 入院率以及死亡率和住院时间与普通人群中的 COVID-19 患者相似。我们的初步经验表明，患有 AIDR 的患者似乎更容易感染 SARS-CoV-2，并且可能有发生严重但不太可能发生危重症疾病的风险。需要进一步研究来了解这些疾病的免疫学特征。
