Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
JAMA Netw Open. 2020 Dec 1;3(12):e2028477. doi: 10.1001/jamanetworkopen.2020.28477.
Posttraumatic stress disorder (PTSD) has been associated with impaired educational performance. Previous studies on the disorder could not control for important measured and unmeasured confounders.
To prospectively investigate the association between PTSD and objective indicators of educational attainment across the life span, controlling for familial factors shared by full siblings, psychiatric comorbidity, and general cognitive ability.
DESIGN, SETTING, AND PARTICIPANTS: This population-based cohort study included 2 244 193 individuals born in Sweden between January 1, 1973, and December 31, 1997, who were followed-up until December 31, 2013. Clusters of full siblings were used to account for familial factors. Data analyses were conducted between December 2018 and May 2020.
International Classification of Diseases, Ninth Revision and International Statistical Classification of Diseases and Related Health Problems, Tenth Revision diagnoses of PTSD in the Swedish National Patient Register.
Eligibility to access upper secondary education after finishing compulsory education, finishing upper secondary education, starting a university degree, and finishing a university degree.
Of the final cohort of 2 244 193 individuals (1 151 414 [51.3%] men) included in the analysis, 1 425 326 were assessed for finishing compulsory education (919 with PTSD), 2 001 944 for finishing upper secondary education (2013 with PTSD), and 1 796 407 and 1 356 741 for starting and finishing a university degree (2243 and 2254 with PTSD, respectively). Posttraumatic stress disorder was associated with lower odds of achieving each of the educational milestones during the study period, including 82% lower odds of finishing compulsory education (adjusted odds ratio [aOR], 0.18; 95% CI, 0.15-0.20), 87% lower odds of finishing upper secondary education (aOR, 0.13; 95% CI, 0.12-0.14), 68% lower odds of starting a university degree (aOR, 0.32; 95% CI, 0.28-0.35), and 73% lower odds of finishing a university degree (aOR, 0.27; 95% CI, 0.23-0.31). Estimates in the sibling comparison were attenuated (aOR range, 0.22-0.53) but remained statistically significant. Overall, excluding psychiatric comorbidities and adjusting for the successful completion of the previous milestone and general cognitive ability did not statistically significantly alter the magnitude of the associations.
Posttraumatic stress disorder was associated with educational impairment across the life span, and the associations were not entirely explained by shared familial factors, psychiatric comorbidity, or general cognitive ability. This finding highlights the importance of implementing early trauma-informed interventions in schools and universities to minimize the long-term socioeconomic consequences of academic failure in individuals with PTSD.
创伤后应激障碍(PTSD)与受教育表现受损有关。以前对该疾病的研究无法控制重要的测量和未测量的混杂因素。
前瞻性研究 PTSD 与整个生命周期中客观教育成就指标之间的关联,同时控制全同胞共同的家庭因素、精神共病和一般认知能力。
设计、地点和参与者:这项基于人群的队列研究纳入了 1973 年 1 月 1 日至 1997 年 12 月 31 日期间在瑞典出生的 2244193 人,随访至 2013 年 12 月 31 日。全同胞聚类用于解释家庭因素。数据分析于 2018 年 12 月至 2020 年 5 月进行。
瑞典国家患者登记处中创伤后应激障碍的国际疾病分类,第 9 版和国际疾病分类,第 10 版修订本诊断。
完成义务教育后接受高等教育的资格、完成中等教育、开始大学学位和完成大学学位。
在最终的 2244193 名参与者队列中(1151414 名[51.3%]男性),1425326 人接受了完成义务教育的评估(919 人患有 PTSD),2001944 人接受了完成中等教育的评估(2013 人患有 PTSD),1796407 人和 1356741 人接受了开始和完成大学学位的评估(分别有 2243 人和 2254 人患有 PTSD)。创伤后应激障碍与研究期间每个教育里程碑的完成几率较低相关,包括完成义务教育的几率低 82%(调整后的优势比 [aOR],0.18;95%CI,0.15-0.20)、完成中等教育的几率低 87%(aOR,0.13;95%CI,0.12-0.14)、开始大学学位的几率低 68%(aOR,0.32;95%CI,0.28-0.35)和完成大学学位的几率低 73%(aOR,0.27;95%CI,0.23-0.31)。同胞比较中的估计值减弱(aOR 范围,0.22-0.53),但仍具有统计学意义。总体而言,排除精神共病并调整前一里程碑的成功完成情况和一般认知能力并不能显著改变关联的幅度。
创伤后应激障碍与整个生命周期的教育障碍有关,这些关联并非完全由共同的家庭因素、精神共病或一般认知能力解释。这一发现强调了在学校和大学实施早期创伤知情干预的重要性,以最大限度地减少 PTSD 个体学业失败的长期社会经济后果。