McKenzie Costner, Silverberg Jonathan I
From the *Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL †Department of Dermatology, George Washington University School of Medicine and Health Sciences, DC.
Dermatitis. 2020 Jan-Feb;31(1):75-80. doi: 10.1097/DER.0000000000000548.
Atopic dermatitis (AD) is a chronic, inflammatory skin disease associated with considerable burden and mental health symptoms. We sought to determine the association of maternal depression in the postpartum period and maternal and paternal depression in later childhood with AD prevalence and persistence in US children. Data were analyzed from the Fragile Families and Child Wellbeing Study, a prospective cohort study of 4898 children born in 20 metropolitan US cities. History of postpartum depression was associated with childhood AD overall (multivariable logistic regression; adjusted odds ratio [aOR], 1.32; 95% confidence interval [CI], 1.06-1.64), and particularly at ages 5 years (aOR, 1.34; 95% CI, 1.04-1.73) and 9 years (aOR, 1.37; 95% CI, 1.10-1.70). Postpartum depression was associated with more persistent AD (present at 2 years: aOR, 1.58; 95% CI, 1.12-2.22; 3 years: aOR, 1.73; 95% CI, 1.15-2.60). Maternal depression in the past year was associated with significantly higher odds of AD at age 5 years (aOR, 1.54; 95% CI, 1.20-1.99), 9 years (aOR, 1.36; 95% CI, 1.10-1.71), and 15 years (aOR, 1.43; 95% CI, 1.13-1.80). Maternal depression was associated with higher odds of AD during 1 year (aOR, 1.50; 95% CI, 1.16-1.94), 2 years (aOR, 1.60; 95% CI, 1.16-2.19), or all 3 years of interviews (aOR, 1.61; 95% CI, 1.06-2.45). In conclusion, maternal depression in the postpartum period and beyond is associated with AD throughout childhood and adolescence.
特应性皮炎（AD）是一种慢性炎症性皮肤病，会带来相当大的负担和心理健康症状。我们试图确定产后母亲抑郁以及儿童期后期母亲和父亲抑郁与美国儿童AD患病率及持续情况之间的关联。数据来自“脆弱家庭与儿童福祉研究”，这是一项对美国20个大城市出生的4898名儿童进行的前瞻性队列研究。产后抑郁史与儿童期AD总体相关（多变量逻辑回归；调整优势比[aOR]为1.32；95%置信区间[CI]为1.06 - 1.64），在5岁（aOR为1.34；95% CI为1.04 - 1.73）和9岁时尤其相关（aOR为1.37；95% CI为1.10 - 1.70）。产后抑郁与更持久的AD相关（2岁时出现：aOR为1.58；95% CI为1.12 - 2.22；3岁时：aOR为1.73；95% CI为1.15 - 2.60）。过去一年母亲抑郁与5岁（aOR为1.54；95% CI为1.20 - 1.99）、9岁（aOR为1.36；95% CI为1.10 - 1.71）和15岁（aOR为1.43；95% CI为1.13 - 1.80）时AD的较高患病几率显著相关。母亲抑郁与1年（aOR为1.50；95% CI为1.16 - 1.94）、2年（aOR为1.60；95% CI为1.16 - 2.19）或所有3年访谈期间AD的较高患病几率相关（aOR为1.61；95% CI为1.06 - 2.45）。总之，产后及产后以外时期母亲抑郁与整个儿童期和青少年期的AD相关。
