Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Endocrinology, Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Otolaryngol Head Neck Surg. 2021 Jul;165(1):223-231. doi: 10.1177/0194599820975432. Epub 2020 Dec 8.
To investigate the clinical characteristics and surgical outcomes of sinonasal tumors associated with tumor-induced osteomalacia (TIO).
Retrospective case series.
Single tertiary center.
We studied the clinical characteristics and surgical outcomes of 43 patients (22 male, 21 female) who had lesions in the nasal cavity and paranasal sinus associated with TIO and underwent surgery between August 2006 and November 2019.
The mean ± SD duration between the onset of symptoms and surgery was 3.9 ± 2.6 years. The most common tumor site was the ethmoid sinus (76.7%), and the skull base was involved in 12 cases. Phosphaturic mesenchymal tumors were diagnosed in 41 patients, among whom there was 1 multifocal case. Another 2 cases involved odontogenic fibroma and hemangiofibroma, respectively. Serum phosphorus normalized in 39 cases within 4.4 ± 2.3 days, and serum fibroblastic growth factor 23 normalized within 1 day; clinical symptoms, however, gradually improved within several months after the first operation. There was no significant difference in the recovery rate between endoscopic and open surgery ( = 0.639). Two patients with recurrent cases and 2 with nonremission cases recovered after a sinonasal reoperation. The patient with a multifocal case recovered after the resection of the tumors in the ethmoid sinus and mandible. The overall recovery rate was 97.7%.
Most sinonasal tumors associated with TIO are located in the ethmoid sinus, and the skull base is involved in some cases. Complete excision of the tumor leads to recovery, and endoscopic surgery could achieve recovery rates similar to those of open surgery.
研究与肿瘤诱导性骨软化症（TIO）相关的鼻窦肿瘤的临床特征和手术结果。
回顾性病例系列研究。
单中心。
我们研究了 2006 年 8 月至 2019 年 11 月期间在鼻腔和鼻窦有与 TIO 相关病变并接受手术的 43 例（22 例男性，21 例女性）患者的临床特征和手术结果。
症状出现和手术之间的平均时间为 3.9 ± 2.6 年。最常见的肿瘤部位是筛窦（76.7%），12 例累及颅底。41 例患者诊断为磷酸质间充质肿瘤，其中 1 例为多灶性。另外 2 例分别为牙源性纤维瘤和血管纤维瘤。39 例患者血清磷在 4.4 ± 2.3 天内恢复正常，血清成纤维细胞生长因子 23 在 1 天内恢复正常；然而，临床症状在第一次手术后的几个月内逐渐改善。内镜手术和开放手术的恢复率无显著差异（=0.639）。2 例复发病例和 2 例未缓解病例在鼻-鼻窦再手术后恢复。1 例多灶性病例在切除筛窦和下颌骨肿瘤后恢复。总体恢复率为 97.7%。
大多数与 TIO 相关的鼻窦肿瘤位于筛窦，有些病例累及颅底。肿瘤完全切除可导致恢复，内镜手术可达到与开放手术相似的恢复率。
