Department of Biology - Zoophysiology, Aarhus University, 8000 Aarhus C, Denmark; Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, Ontario K1N 6N5, Canada.
Department of Biology - Zoophysiology, Aarhus University, 8000 Aarhus C, Denmark.
Comp Biochem Physiol A Mol Integr Physiol. 2021 Mar;253:110861. doi: 10.1016/j.cbpa.2020.110861. Epub 2020 Dec 5.
August Krogh pioneered a view of cardiac output that emphasised the rate of venous return, and stressed the importance of changing the filling of the 'inadequately' supplied heart, instead of changes in heart rate or cardiac inotropy. Krogh, by and large, presented this concept in three manuscripts published in 1912, which relied on innovative experimental techniques (developed in collaboration with Johannes Lindhard) as well as mathematical and physical models. In this graphical review, we revisit Krogh's original articles, demonstrate how they have stood the test of time, and show how they are relevant to comparative cardiovascular physiology. In doing so, we present an overview of the fundamental, but sometimes counterintuitive, principle that peripheral factors are at least as important as cardiac function in determining cardiac output.
奥古斯特·克罗赫开创了一种强调静脉回流速率的心脏输出观点，并强调了改变“供应不足”心脏充盈的重要性，而不是改变心率或心肌变力。克罗赫主要在 1912 年发表的三篇论文中提出了这一概念，这些论文依赖于创新的实验技术（与约翰内斯·林德哈特合作开发）以及数学和物理模型。在这篇图形综述中，我们重新审视了克罗赫的原始论文，展示了它们如何经受住了时间的考验，并展示了它们与比较心血管生理学的相关性。在这样做的过程中，我们介绍了一个基本但有时违反直觉的原则，即外周因素至少与心脏功能一样重要，决定了心输出量。
