Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Clinic of Medicine, St. Olavs Hospital, Trondheim, Norway; Faculty of Biology, Institute of Biology III, University of Freiburg, 79104, Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104, Freiburg, Germany.
Faculty of Biology, Institute of Biology III, University of Freiburg, 79104, Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104, Freiburg, Germany.
Cancer Lett. 2021 Mar 31;501:105-113. doi: 10.1016/j.canlet.2020.11.042. Epub 2020 Dec 5.
Many cell signaling pathways are activated or deactivated by protein tyrosine phosphorylation and dephosphorylation, catalyzed by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), respectively. Even though PTPs are as important as PTKs in this process, their role has been neglected for a long time. Multiple myeloma (MM) is a cancer of plasma cells, which is characterized by production of monoclonal immunoglobulin, anemia and destruction of bone. MM is still incurable with high relapse frequency after treatment. In this review, we highlight the PTPs that were previously described in MM or have a role that can be relevant in a myeloma context. Our purpose is to show that despite the importance of PTPs in MM pathogenesis, many unanswered questions in this field need to be addressed. This might help to detect novel treatment strategies for MM patients.
许多细胞信号通路通过蛋白质酪氨酸的磷酸化和去磷酸化被激活或失活，分别由蛋白质酪氨酸激酶（PTKs）和蛋白质酪氨酸磷酸酶（PTPs）催化。尽管 PTPs 在这个过程中与 PTKs 同样重要，但它们的作用长期以来一直被忽视。多发性骨髓瘤（MM）是一种浆细胞瘤，其特征是单克隆免疫球蛋白的产生、贫血和骨骼破坏。在治疗后，MM 仍然无法治愈，且复发频率很高。在这篇综述中，我们重点介绍了先前在 MM 中描述过的 PTPs 或在骨髓瘤环境中具有相关作用的 PTPs。我们的目的是表明，尽管 PTPs 在 MM 发病机制中很重要，但该领域仍有许多悬而未决的问题需要解决。这可能有助于为 MM 患者发现新的治疗策略。
