高脂肪饮食诱导 APPswe/PS1dE9 型和野生型 C57BL/6J 小鼠外周和中枢神经系统胰岛素抵抗的差异。 - Suppr

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超能文献

High-fat diet induced discrepant peripheral and central nervous systems insulin resistance in APPswe/PS1dE9 and wild-type C57BL/6J mice.

机构信息

School of Public Health, Capital Medical University, Beijing 100069, P.R. China.

出版信息

Aging (Albany NY). 2020 Dec 3;13(1):1236-1250. doi: 10.18632/aging.202262.

DOI:10.18632/aging.202262

PMID:33291072

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7835010/

Abstract

摘要

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Acta Pharmacol Sin. 2019 Oct;40(10):1259-1268. doi: 10.1038/s41401-019-0239-3. Epub 2019 May 14.

Understanding the link between insulin resistance and Alzheimer's disease: Insights from animal models.理解胰岛素抵抗与阿尔茨海默病之间的联系：动物模型的启示。

Exp Neurol. 2019 Jun;316:1-11. doi: 10.1016/j.expneurol.2019.03.016. Epub 2019 Mar 28.

Beta-amyloid short- and long-term synaptic entanglement.β-淀粉样短程和长程突触纠缠。

Pharmacol Res. 2019 Jan;139:243-260. doi: 10.1016/j.phrs.2018.11.018. Epub 2018 Nov 22.

Long-term exposure to high-sucrose diet down-regulates hepatic endoplasmic reticulum-stress adaptive pathways and potentiates de novo lipogenesis in weaned male mice.长期摄入高蔗糖饮食会下调断奶雄性小鼠肝脏内质网应激适应性途径，并增强从头脂肪生成。

J Nutr Biochem. 2018 Dec;62:155-166. doi: 10.1016/j.jnutbio.2018.09.007. Epub 2018 Sep 19.

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Insulin transport across the blood-brain barrier can occur independently of the insulin receptor.胰岛素可以通过血脑屏障进行转运，而这一过程与胰岛素受体无关。

J Physiol. 2018 Oct;596(19):4753-4765. doi: 10.1113/JP276149. Epub 2018 Aug 28.

The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins.2型糖尿病与神经退行性变之间的联系：β-淀粉样蛋白、胰岛淀粉样多肽和tau蛋白的作用

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