Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
BMJ Open. 2020 Dec 7;10(12):e035805. doi: 10.1136/bmjopen-2019-035805.
To explore the association between age-related macular degeneration (AMD) and arthritis in a representative sample of the US population.
Population-based, cross-sectional study.
The National Health and Nutrition Examination Survey (NHANES) 2005-2008.
A total of 4813 participants aged 40 years and older with available information on AMD and arthritis in the 2005-2008 NHANES.
The status and types of arthritis were obtained from questionnaires. Non-mydriatic fundus photographs were collected. The types of AMD were assessed using the modified Wisconsin Age-Related Maculopathy Grading Classification Scheme. The association between arthritis and AMD was evaluated using logistic regression models.
After adjusting for covariates, participants with any or early AMD had significantly lower odds of having any type of arthritis (any AMD: OR=0.56, 95% CI: 0.36-0.86; early AMD: OR=0.55, 95% CI: 0.34-0.88) or osteoarthritis (OA) (any AMD: OR=0.43, 95% CI: 0.26-0.71; early AMD: OR=0.44, 95% CI: 0.25-0.76) compared with those without AMD. When considering AMD as the outcome, significant negative associations were also found between any arthritis or OA and any (any arthritis: OR=0.64, 95% CI: 0.43-0.94; OA: OR=0.52, 95% CI: 0.33-0.82) or early AMD (any arthritis: OR=0.61, 95% CI: 0.40-0.93; OA: OR=0.51, 95% CI: 0.31-0.86) in the multivariable logistic models. There was no significant association between different types of arthritis and late AMD.
People with arthritis, especially those with OA, were less likely to have AMD compared with those without arthritis and vice versa. Further studies are needed to confirm this potential protective effect of arthritis and/or arthritis treatment on AMD and to explore the underlying mechanisms.
在具有代表性的美国人群样本中，探索年龄相关性黄斑变性（AMD）与关节炎之间的关联。
基于人群的横断面研究。
2005-2008 年国家健康和营养调查（NHANES）。
共有 4813 名年龄在 40 岁及以上的参与者，他们在 2005-2008 年 NHANES 中提供了有关 AMD 和关节炎的信息。
通过问卷获得关节炎的状况和类型。收集非散瞳眼底照片。使用改良的威斯康星州年龄相关性黄斑病变分级分类方案评估 AMD 的类型。使用逻辑回归模型评估关节炎与 AMD 之间的关联。
在调整了协变量后，患有任何或早期 AMD 的参与者患任何类型关节炎（任何 AMD：OR=0.56，95%CI：0.36-0.86；早期 AMD：OR=0.55，95%CI：0.34-0.88）或骨关节炎（OA）（任何 AMD：OR=0.43，95%CI：0.26-0.71；早期 AMD：OR=0.44，95%CI：0.25-0.76）的可能性显著降低。当将 AMD 视为结果时，任何关节炎或 OA 与任何（任何关节炎：OR=0.64，95%CI：0.43-0.94；OA：OR=0.52，95%CI：0.33-0.82）或早期 AMD（任何关节炎：OR=0.61，95%CI：0.40-0.93；OA：OR=0.51，95%CI：0.31-0.86）之间也存在显著的负相关。在多变量逻辑模型中，不同类型的关节炎与晚期 AMD 之间没有显著关联。
与没有关节炎的人相比，患有关节炎的人，尤其是患有 OA 的人，患 AMD 的可能性较小，反之亦然。需要进一步的研究来证实关节炎和/或关节炎治疗对 AMD 的潜在保护作用，并探讨潜在的机制。
