Department of Laboratory Medicine, First Hospital of Jilin University, Changchun 130021, China.
Department of Pediatrics, First Hospital of Jilin University, Changchun 130021, China.
J Immunol Res. 2020 Nov 18;2020:5679254. doi: 10.1155/2020/5679254. eCollection 2020.
T follicular helper (TFH) cells are recognized as a subtype of T cells that are involved in the germinal center formation and B cell development. When dysregulated, TFH cells may represent an important mechanism that contributes to a heightened humoral response and autoantibody production in autoimmune liver diseases (AILDs). TFH cells participate in the immune response associated with AILDs by expressing surface receptors such as programmed cell death protein-1, C-X-C motif chemokine receptor 5, and inducible T cell costimulators, as well as cytokines such as interleukin-21. TFH cells also downregulate chemokine (C-C motif) receptor 7 and promote the dysregulation of the T follicular regulatory/TFH axis. This review highlights the importance of TFH cells in AILDs.
滤泡辅助 T 细胞（TFH 细胞）是一种参与生发中心形成和 B 细胞发育的 T 细胞亚群。当失调时，TFH 细胞可能代表一种重要的机制，有助于自身免疫性肝病（AILDs）中增强的体液免疫反应和自身抗体产生。TFH 细胞通过表达程序性细胞死亡蛋白-1、C-X-C 基序趋化因子受体 5 和诱导型 T 细胞共刺激物等表面受体以及白细胞介素-21 等细胞因子参与与 AILD 相关的免疫反应。TFH 细胞还下调趋化因子（C-C 基序）受体 7 并促进 T 滤泡调节/TFH 轴的失调。本综述强调了 TFH 细胞在 AILDs 中的重要性。
