Kizildag Yirgin Inci, Has Duygu, Arslan Gozde, Aydin Esra Cureoglu, Sari Murat, Onder Semen, Yasemin Sanli, Cabioglu Neslihan, Karanlik Hasan, Tukenmez Mustafa, Dursun Memduh, Muslumanoglu Mahmut, Ozmen Vahit
Department of Radiology, Oncology Institute, Istanbul University, Istanbul, 34390, Capa, Turkey.
Department of Nuclear Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, 34390, Capa, Turkey.
Eur J Radiol Open. 2020 Nov 19;7:100286. doi: 10.1016/j.ejro.2020.100286. eCollection 2020.
To compare the adipose and muscle tissue areas in patients who responded differently to neoadjuvant chemotherapy.
One hundred and eighty six patients diagnosed with breast cancer who underwent neoadjuvant chemotherapy between January 2015- October 2019 and were operated after the treatment were retrospectively included in the study. Pathological results were divided into five groups using the Miller-Payne grading systems. Grade 1 indicating no significant reduction in malignant cells; Grade 2: a minor loss of malignant cells (≤ 30 %); Grade 3: reduction in malignant cells between 30 % and 90 %; Grade 4: disappearance of malignant cells >90 %; Grade 5: no malignant cells identifiable. Pre-treatment PET CT scans were evaluated, and calculation of body composition parameters were performed on a single axial section passing through the L3 vertebrae. Spearman's correlation test was used to analyze the correlation between SAT, VAT, MT parameters and pathological responses.
There was no strong correlation between the 5 groups separated according to neoadjuvant chemotherapy treatment response and tissue distributions. However, that there was a very low correlation found between superficial adipose tissue and pathological response (r=, 156).
In conclusion, our results have provided a very low correlation between SAT and more than 30 % response. More research is required to evaluate the role of the body fat and muscle parameters in response to neoadjuvant chemotherapy in larger patient populations.
比较对新辅助化疗反应不同的患者的脂肪组织和肌肉组织面积。
回顾性纳入2015年1月至2019年10月期间接受新辅助化疗并在治疗后接受手术的186例乳腺癌患者。使用Miller-Payne分级系统将病理结果分为五组。1级表示恶性细胞无明显减少；2级：恶性细胞轻度减少（≤30%）；3级：恶性细胞减少30%至90%；4级：恶性细胞消失>90%；5级：无法识别恶性细胞。评估治疗前的PET CT扫描，并在通过L3椎体的单个轴位切片上进行身体成分参数计算。采用Spearman相关性检验分析皮下脂肪组织（SAT）、内脏脂肪组织（VAT）、肌肉组织（MT）参数与病理反应之间的相关性。
根据新辅助化疗治疗反应划分的5组与组织分布之间没有很强的相关性。然而，发现浅表脂肪组织与病理反应之间存在非常低的相关性（r = 0.156）。
总之，我们的结果表明SAT与超过30%的反应之间存在非常低的相关性。需要更多研究来评估身体脂肪和肌肉参数在更大患者群体对新辅助化疗反应中的作用。
