Rahmati Batool, Zaeri Fatemeh, Heydari Azhdar
Neurophysiology Research Center, Shahed University, 1417953836, Tehran, Iran.
Department of Physiology, School of Medicine, Shahed University, 3319118651, Tehran, Iran.
Heliyon. 2020 Nov 25;6(11):e05579. doi: 10.1016/j.heliyon.2020.e05579. eCollection 2020 Nov.
In Iran, both - the endemic species of Nepeta genus - and are known as Ustukhuddoos and used widely as medicinal herbs. In Iranian traditional medicine, Ustukhuddoos has been recommended for several neuronal diseases including depression and epilepsy. While the antiepileptic effects of have been investigated in a number of studies, no reports are available taking into account the effect of on epilepsy. Since convulsion is an important side effect of some medicinal plants, a thorough study of the effects of on epilepsy seems necessary. This study was designed to investigate the potential anti- or pro-convulsant activity of and its effects on oxidative stress markers. Since an herbal medicine showed opposite effects in two animal models of epilepsy in our laboratory, authers decided to study Nepeta effects through several seizure tests including the intravenous pentylenetetrazol (i.v. PTZ) infusion, the maximal electroshock (MES), acute PTZ and PTZ-kindling tests. These seizure models are generally used for screening pro- or anti-epileptic drugs. (400 mg/kg) significantly reduced the dose of PTZ necessary for clonus seizure induction. Combining either phenytoin (Phen) or Valproate (Val) with Nepeta decreased their antiepileptic effects. Therefore, not only failed to prevent the seizures but also increased sensitivity to them. Nepeta raised brain NO levels in different seizure tests. It seems there is a relation between NO elevation by Nepeta and increased sensitivity to seizures that should be investigated later.
在伊朗，荆芥属的两个地方特有物种——[此处原文缺失两个物种名称]，都被称为“Ustukhuddoos”，并被广泛用作草药。在伊朗传统医学中，“Ustukhuddoos”已被推荐用于治疗包括抑郁症和癫痫在内的多种神经系统疾病。虽然已有多项研究对[此处原文缺失物种名称]的抗癫痫作用进行了调查，但尚未有关于[此处原文缺失物种名称]对癫痫影响的报道。由于惊厥是一些药用植物的重要副作用，因此对[此处原文缺失物种名称]对癫痫的影响进行全面研究似乎很有必要。本研究旨在调查[此处原文缺失物种名称]的潜在抗惊厥或促惊厥活性及其对氧化应激标志物的影响。由于一种草药在我们实验室的两种癫痫动物模型中显示出相反的作用，作者决定通过几种癫痫发作测试来研究荆芥的作用，包括静脉注射戊四氮（i.v. PTZ）、最大电休克（MES）、急性PTZ和PTZ点燃测试。这些癫痫发作模型通常用于筛选抗癫痫或促癫痫药物。[此处原文缺失物种名称]（400毫克/千克）显著降低了诱导阵挛性癫痫发作所需的PTZ剂量。将苯妥英（Phen）或丙戊酸盐（Val）与荆芥联合使用会降低它们的抗癫痫作用。因此，[此处原文缺失物种名称]不仅未能预防癫痫发作，反而增加了对癫痫发作的敏感性。在不同的癫痫发作测试中，荆芥提高了大脑中的一氧化氮（NO）水平。荆芥引起的NO升高与癫痫发作敏感性增加之间似乎存在关联，这一点有待进一步研究。
