草药组合（L.和Boiss.及Buhse）对失眠症患者失眠严重程度、焦虑和抑郁的影响：随机安慰剂对照试验。
Effects of Herbal combination ( L. and Boiss. & Buhse) on insomnia severity, anxiety and depression in insomniacs: Randomized placebo controlled trial.
作者信息
Ranjbar Maryam, Firoozabadi Ali, Salehi Alireza, Ghorbanifar Zahra, Zarshenas Mohammad M, Sadeghniiat-Haghighi Khosro, Rezaeizadeh Hossein
机构信息
Research Centre for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Research Centre for Psychiatry and Behavioral Sciences, Department of Psychiatry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Integr Med Res. 2018 Dec;7(4):328-332. doi: 10.1016/j.imr.2018.08.001. Epub 2018 Aug 10.
BACKGROUND
Insomnia is a prevalent disorder leading to psychological problems such as anxiety and depression.
METHODS
This study investigates the effect of a combination of herbs ( L. and Boiss. & Buhse) on anxiety and depression for insomniacs and on insomnia severity. This study is a double-blind randomized placebo-controlled clinical trial. A total number of 67 participants met the inclusion criteria who were diagnosed as cases of insomnia. The patients were randomized into the herbal treatment or placebo groups. The herbal treatment group received a combination of and Boiss. & Buhse. The primary outcomes were insomnia, depression and anxiety. We used per-protocol analysis.
RESULTS
The all outcomes of herbal treatment were significantly improved compared with placebo in the ISI, BAI and BDI scores after four weeks' treatment ( value: 0.008, 0.005 and <0.001 respectively).
CONCLUSION
A combination of L. and Boiss. & Buhse may improve insomnia and its comorbid depression and anxiety.
背景
失眠是一种常见疾病，会引发焦虑和抑郁等心理问题。
方法
本研究调查了一种草药组合（L.以及Boiss.和Buhse）对失眠症患者焦虑和抑郁的影响以及对失眠严重程度的影响。本研究是一项双盲随机安慰剂对照临床试验。共有67名符合纳入标准的参与者被诊断为失眠症患者。患者被随机分为草药治疗组或安慰剂组。草药治疗组接受L.和Boiss.及Buhse的组合治疗。主要结局指标为失眠、抑郁和焦虑。我们采用符合方案分析。
结果
治疗四周后，与安慰剂相比，草药治疗组在ISI、BAI和BDI评分方面的所有结局指标均有显著改善（P值分别为0.008、0.005和<0.001）。
结论
L.和Boiss.及Buhse的组合可能改善失眠及其合并的抑郁和焦虑。
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