Duijvelshoff Renee, Cabrera Maria S, Sanders Bart, Dekker Sylvia, Smits Anthal I P M, Baaijens Frank P T, Bouten Carlijn V C
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Institute for Complex Molecular Systems, Eindhoven, the Netherlands.
JACC Basic Transl Sci. 2020 Nov 23;5(11):1095-1110. doi: 10.1016/j.jacbts.2020.09.005. eCollection 2020 Nov.
As the next step in the translation of vascular tissue engineering, this study uniquely combines transcatheter delivery and in situ tissue regeneration using a novel bioresorbable electrospun polymer graft that can be implanted minimally invasively. Once delivered inside a small-diameter vessel, the electrospun microstructure supports the vessel wall, facilitates cellular infiltration, and guides organized tissue formation.
作为血管组织工程转化的下一步,本研究独特地结合了经导管递送和原位组织再生,使用一种新型的可生物降解电纺聚合物移植物,该移植物可通过微创方式植入。一旦递送至小直径血管内,电纺微结构可支撑血管壁,促进细胞浸润,并引导有组织的组织形成。