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具有支架功能的经导管输送可扩张生物可吸收聚合物移植物可诱导血管再生。

Transcatheter-Delivered Expandable Bioresorbable Polymeric Graft With Stenting Capacity Induces Vascular Regeneration.

作者信息

Duijvelshoff Renee, Cabrera Maria S, Sanders Bart, Dekker Sylvia, Smits Anthal I P M, Baaijens Frank P T, Bouten Carlijn V C

机构信息

Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.

Institute for Complex Molecular Systems, Eindhoven, the Netherlands.

出版信息

JACC Basic Transl Sci. 2020 Nov 23;5(11):1095-1110. doi: 10.1016/j.jacbts.2020.09.005. eCollection 2020 Nov.

Abstract

As the next step in the translation of vascular tissue engineering, this study uniquely combines transcatheter delivery and in situ tissue regeneration using a novel bioresorbable electrospun polymer graft that can be implanted minimally invasively. Once delivered inside a small-diameter vessel, the electrospun microstructure supports the vessel wall, facilitates cellular infiltration, and guides organized tissue formation.

摘要

作为血管组织工程转化的下一步,本研究独特地结合了经导管递送和原位组织再生,使用一种新型的可生物降解电纺聚合物移植物,该移植物可通过微创方式植入。一旦递送至小直径血管内,电纺微结构可支撑血管壁,促进细胞浸润,并引导有组织的组织形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0338/7691284/a30e2b1ef04d/fx1.jpg

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