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2002-2016 年圣保罗市乙型肝炎和丙型肝炎导致的死亡率趋势。

Mortality trend due to Hepatitis B and C in the city of São Paulo, 2002-2016.

机构信息

Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Epidemiologia. São Paulo, SP, Brasil.

Secretaria de Estado da Saúde de São Paulo. Coordenadoria de Controle de Doenças. Centro de Vigilância Epidemiológica "Prof. Alexandre Vranjac". São Paulo, SP, Brasil.

出版信息

Rev Saude Publica. 2020 Dec 4;54:124. doi: 10.11606/s1518-8787.2020054002231. eCollection 2020.

DOI:10.11606/s1518-8787.2020054002231
PMID:33295592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7688257/
Abstract

OBJECTIVE

To describe mortality due to hepatitis B and C as underlying cause in the municipality of São Paulo, verifying the trend of these rates, and to assess the association of these diseases with others, from 2002 to 2016.

METHODS

This is a time series study on mortality due to hepatitis B and C according to sex, with data from the Sistema de Informação de Mortalidade (SIM - Mortality Information Sistem). Prais Winsten regression was used in rate trend analysis.

RESULTS

The findings of this study showed a trend of decline of mortality from hepatitis B and C in recent years, particularly among males. These infections were important associated causes of liver cell carcinoma and HIV. The proportion of deaths under 70 years of age stands out.

CONCLUSIONS

The study provides a baseline for research on mortality trend and the impact of interventions, given the history of expanded detection and supply of treatments, including the most recent antivirals in Brazil, since 2015.

摘要

目的

描述 2002 年至 2016 年期间，圣保罗市乙型肝炎和丙型肝炎作为根本死因导致的死亡率，检验这些比率的变化趋势，并评估这些疾病与其他疾病的相关性。

方法

这是一项关于乙型肝炎和丙型肝炎死亡率的时间序列研究，按性别进行分类，数据来自 Sistema de Informação de Mortalidade（SIM-死亡率信息系统）。采用普赖斯-温斯坦回归进行比率趋势分析。

结果

本研究结果显示，近年来乙型肝炎和丙型肝炎导致的死亡率呈下降趋势，尤其是在男性中。这些感染是肝癌和 HIV 的重要相关病因。70 岁以下年龄段的死亡比例尤为突出。

结论

鉴于巴西自 2015 年以来扩大了检测和治疗供应（包括最新的抗病毒药物）的历史，本研究为死亡率趋势和干预效果的研究提供了基线数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ca1/7688257/a6e7ae96c2f2/1518-8787-rsp-54-124-gf02-pt.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ca1/7688257/ec76ddc55f9f/1518-8787-rsp-54-124-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ca1/7688257/0a32c6c7eb9b/1518-8787-rsp-54-124-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ca1/7688257/a772bcb36ea4/1518-8787-rsp-54-124-gf01-pt.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ca1/7688257/a6e7ae96c2f2/1518-8787-rsp-54-124-gf02-pt.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ca1/7688257/ec76ddc55f9f/1518-8787-rsp-54-124-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ca1/7688257/0a32c6c7eb9b/1518-8787-rsp-54-124-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ca1/7688257/a772bcb36ea4/1518-8787-rsp-54-124-gf01-pt.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ca1/7688257/a6e7ae96c2f2/1518-8787-rsp-54-124-gf02-pt.jpg

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Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016.全球、地区和国家按年龄、性别划分的 264 种死因的死亡率：2016 年全球疾病负担研究的系统分析。
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