Fadiloglu Erdem, Zaim Onur Can, Cagan Murat, Unal Canan, Beksac M Sinan
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Fetal Pediatr Pathol. 2022 Aug;41(4):551-557. doi: 10.1080/15513815.2020.1856245. Epub 2020 Dec 9.
We evaluated if there were more adverse gestational outcomes of pregnant women with unilateral congenital renal agenesis (UCRA). This single center retrospective case-control study compared maternal complications and neonatal outcomes from 25 women with UCRA to the outcomes of 125 women with two kidneys. UCRA women had lower gestational weeks at birth and higher rates of preterm delivery ( = 0.004 and <0.001; respectively). Mothers had higher rates of preeclampsia and newborns with congenital anomalies and neonatal intensive care unit (NICU) admission ( = 0.009, 0.042, and 0.039; respectively). Unadjusted odds ratios were significantly higher for preterm delivery and for any APGAR score of <7 at the first 10 min and preeclampsia [OR (95% CI):13.5 (4.66-39.05), 31 (3.44-279.32) and 5.76 (1.33-24.84), respectively]. Maternal UCRA is a risk factor for less optimal obstetric and neonatal outcomes.
我们评估了单侧先天性肾缺如（UCRA）孕妇是否有更多不良妊娠结局。这项单中心回顾性病例对照研究比较了25例UCRA孕妇的母体并发症和新生儿结局与125例有双侧肾脏孕妇的结局。UCRA孕妇出生时孕周较低，早产率较高（分别为P = 0.004和<0.001）。母亲患先兆子痫的比例较高，新生儿患先天性异常及入住新生儿重症监护病房（NICU）的比例也较高（分别为P = 0.009、0.042和0.039）。早产、出生后10分钟时任何Apgar评分<7以及先兆子痫的未调整比值比均显著更高[比值比（95%置信区间）：分别为13.5（4.66 - 39.05）、31（3.44 - 279.32）和5.76（1.33 - 24.84）]。母体UCRA是导致产科和新生儿结局欠佳的一个危险因素。
