Department of Nutritional Sciences, the University of Arizona, Tucson, Arizona.
Am J Physiol Regul Integr Comp Physiol. 2021 Mar 1;320(3):R287-R296. doi: 10.1152/ajpregu.00185.2020. Epub 2020 Dec 9.
Prostaglandins are critical lipid mediators involved in the wound healing response, with prostaglandin E (PGE) being the most complex and exhibiting the most diverse physiological outputs. PGE signals via four G protein-coupled receptors, termed EP-receptors 1-4 that induce distinct signaling pathways upon activation and lead to an array of different outputs. Recent studies examining the role of PGE and EP receptor signaling in wound healing following various forms of tissue damage are discussed in this review.
前列腺素是参与伤口愈合反应的关键脂质介质，其中前列腺素 E（PGE）最为复杂，表现出最多样化的生理作用。PGE 通过四种 G 蛋白偶联受体（EP 受体 1-4）传递信号，这些受体在激活后诱导不同的信号通路，导致产生一系列不同的作用。本综述讨论了在各种组织损伤后，PGE 和 EP 受体信号在伤口愈合中的作用的最新研究。
