Department of Obstetrics and Gynecology, College of Medicine, King Saud University and King Khalid University Hospital, Riyadh, Saudi Arabia.
Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
J Infect Dev Ctries. 2020 Nov 30;14(11):1306-1313. doi: 10.3855/jidc.13034.
Surgical site infections (SSIs) are a major health issue in surgical specialties in terms of health care costs and patients' clinical outcomes. At the level of the patient, prolonged hospital stays or readmissions for SSIs, can affect the patient's quality of life. At the level of the health care system, it exhausts the hospital's resources and increases the burden on the medical staff due to the need for continuous wound care, microbiological cultures, laboratory tests and medications. In this study, we assessed the effectiveness of two antibiotic prophylaxis regimens for the prevention of SSIs in patients undergoing elective hysterectomy surgeries.
A retrospective cohort, analyzing 141 patients, was conducted between November 2016 and January 2019 at a university hospital. We compared the efficacy of a single dose vs. 24-hour multiple doses of Cefazolin in patients who underwent elective hysterectomy for benign or malignant indications. The secondary objective was to identify potential risk factors associated with SSIs.
There was no statistically significant difference between both groups (p = 0.872). Obesity and a laparotomy surgical approach are risk factors to the development of SSIs (p = 0.001 and 0.014, respectively). Other potential risk factors include the duration of hospital stay, the duration of the surgery and the amount of blood loss.
Although the rate of SSIs is not significantly different between both groups, risk stratification can be done after screening patients and the prophylactic regimen must be tailored for each patient in a cost-effective manner and using a multidisciplinary approach.
在医疗成本和患者临床结果方面，手术部位感染（SSI）是外科专业的一个主要健康问题。就患者而言，因 SSI 而延长住院时间或再次入院，会影响患者的生活质量。就医疗保健系统而言，它会耗尽医院的资源，并由于需要持续的伤口护理、微生物培养、实验室检查和药物治疗而增加医务人员的负担。在这项研究中，我们评估了两种抗生素预防方案在预防择期子宫切除术患者 SSI 中的有效性。
回顾性队列分析，共纳入 141 例患者，于 2016 年 11 月至 2019 年 1 月在一所大学医院进行。我们比较了头孢唑林单次剂量与 24 小时多次剂量在因良性或恶性指征行择期子宫切除术的患者中的疗效。次要目的是确定与 SSI 相关的潜在危险因素。
两组之间无统计学差异（p = 0.872）。肥胖和剖腹手术入路是 SSI 发展的危险因素（p = 0.001 和 0.014）。其他潜在的危险因素包括住院时间、手术持续时间和失血量。
尽管两组 SSI 发生率无显著差异，但可以在筛选患者后进行风险分层，并且必须以经济有效的方式并采用多学科方法为每位患者量身定制预防方案。
