伴有复发性视神经炎和感觉性多发性神经根神经病的MOG抗体相关疾病：一例报告
MOG antibody-related disease with recurrent optic neuritis and sensory polyradiculoneuropathy: A case report.
作者信息
Shima Tomoaki, Tsujino Akira
机构信息
Department of Neurology and Strokology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Department of Neurology and Strokology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
出版信息
Mult Scler Relat Disord. 2020 Nov;46:102597. doi: 10.1016/j.msard.2020.102597. Epub 2020 Oct 21.
Myelin oligodendrocyte glycoprotein (MOG) antibody-related diseases are inflammatory demyelinating conditions of the central nervous system (CNS) that induce a broad spectrum of symptoms. Since MOG is expressed exclusively in the CNS, the lesions are thought to be confined to the CNS. However, few cases of MOG antibody-related disease involve the peripheral nervous system (PNS); the mechanisms underlying such PNS involvement remain unclear. We herein present the case of a patient with MOG antibody-related disease with recurrent optic neuritis and sensory polyradiculoneuropathy unaccompanied by CNS lesions. Our report presents a novel phenotype of PNS involvement in MOG antibody-related disease.
髓鞘少突胶质细胞糖蛋白（MOG）抗体相关疾病是中枢神经系统（CNS）的炎性脱髓鞘疾病，可引发多种症状。由于MOG仅在中枢神经系统中表达，因此病变被认为局限于中枢神经系统。然而，很少有MOG抗体相关疾病累及周围神经系统（PNS）；这种PNS受累的潜在机制仍不清楚。我们在此报告一例患有MOG抗体相关疾病的患者，该患者反复出现视神经炎和感觉性多神经根神经病，且无中枢神经系统病变。我们的报告展示了MOG抗体相关疾病中周围神经系统受累的一种新表型。
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