To understand the relationship between new-type drug use and high risk behavior in men who have sex with men (MSM) in Shandong province. Cross-sectional surveys was conducted to collect the information about demographics, sexual and drug use behaviors of MSM and HIV-related services in MSM in three sentinel surveillance sites in Shandong from April to July in 2019. Blood samples were taken from the MSM for serological tests of HIV antibody and syphilis antibody. A total of 1 203 MSM were included in this study. The average age of the MSM was 30.2±8.9 years. Among these MSM, 67.7 (815) were unmarried; 66.9 (805) had education level of college or above; 62.2 (721/1 160) had unprotected sex behaviors and 16.3 (189/1 160) had group sex behavior in the past six months and 54.2 (652/1 203) ever used new-type drugs. HIV infection and syphilis prevalence rates were 3.1 (37/1 203) and 4.7 (56/1 203), respectively. Multivariable logistic analysis indicated that MSM who had unprotected anal sex in the past six months were more likely to be from Qingdao (a=1.59, 95:1.13-2.23), with education level of high school or below (a=1.61, 95: 1.20-2.16), with male sex partners from bars/dance halls or other venues (a=1.69, 95: 1.06-2.69), with HIV knowledge awareness score <6 (a=1.55, 95: 1.01-2.37), with ≥2 sex partner in the past week (a=1.48, 95: 1.12-1.95), to have group sex behaviors in the past six months (a=2.43, 95:1.61-3.67) and to use new-type drugs (a=1.46, 95: 1.11-1.91). MSM who had group sex were more likely to have following features: being from Qingdao (a=2.21, 95: 1.45-3.38), non-Shandong residents (a=2.13, 95: 1.28-3.55), HIV knowledge awareness score ≥6 (a=3.11, 95: 1.55-6.25), ever having unprotected anal sex behaviors (a=2.60, 95: 1.71-3.96) and ever having male commercial sex (a=3.38, 95: 1.92-5.95) in the past six months, ever using new-type drugs (a=2.71, 95: 1.82-4.04), and never having HIV testing in the past year (a=2.66, 95: 1.59-4.43). New-type drug use is common in MSM in Shandong. The use of new-type drugs promotes unprotected sex and group sex in MSM. Surveillance and intervention measures targeting this population should be strengthened.