Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Yucatán. Carretera Mérida-Xmatkuil Km, Mérida, Yucatán, México.
Crit Rev Food Sci Nutr. 2022;62(10):2673-2682. doi: 10.1080/10408398.2020.1857331. Epub 2020 Dec 10.
Proteins and peptides are fundamental components of the cereals, pseudocereals, and legumes, giving them numerous health-beneficial properties. Previous studies have demonstrated that these molecules exerted effects on current therapeutic targets related to type 2 diabetes mellitus, such as incretin hormones (responsible for appetite suppression), dipeptidyl peptidase IV (an enzyme involved in the inactivation and degradation of the incretin hormones), and glucose transporters (molecules that transport glucose in or out of cells). Therefore, this review presents the current biological activity of protein derivatives and peptides isolated from cereals, pseudocereals, and legumes on these therapeutic markers, highlighting their potential as a possible pharmacological treatment for type 2 diabetes mellitus.
蛋白质和肽是谷物、假谷物和豆类的基本组成部分，使它们具有许多有益健康的特性。先前的研究表明，这些分子对 2 型糖尿病相关的当前治疗靶点发挥作用，如肠降血糖素（负责抑制食欲）、二肽基肽酶 IV（一种参与肠降血糖素失活和降解的酶）和葡萄糖转运体（将葡萄糖进出细胞的分子）。因此，本综述介绍了从谷物、假谷物和豆类中分离得到的蛋白质衍生物和肽对这些治疗标志物的当前生物学活性，强调了它们作为 2 型糖尿病可能的药理学治疗方法的潜力。
