骨髓成纤维细胞的特征及其在造血中的意义。
Characteristics of bone marrow fibroblasts and their significance in hematopoiesis.
作者信息
Nagao T
机构信息
Fourth Department of Internal Medicine, School of Medicine, Tokai University, Japan.
出版信息
Tokai J Exp Clin Med. 1987 Mar;12(1):1-6.
Effective hematopoiesis is thought to be maintained by interplaying between the hematopoietic stem cells (HSC) and their supporting stroma which supply an appropriate environment for HSC lodgement, proliferation and differentiation in the bone marrow. Many experiments have made it apparent that the bone marrow microenvironment is essential for normal hematopoiesis. Several recent reports have shown that most human bone marrow adherent cells under long-term liquid cultures are fibroblasts. In this article, the characteristics of the stromal fibroblasts and their role for HSC maintenance and differentiation are described.
有效的造血作用被认为是通过造血干细胞（HSC）与其支持性基质之间的相互作用来维持的，这种基质为HSC在骨髓中的 lodgement、增殖和分化提供了适宜的环境。许多实验已表明骨髓微环境对正常造血至关重要。最近的一些报告显示，长期液体培养下的大多数人骨髓贴壁细胞是成纤维细胞。本文描述了基质成纤维细胞的特征及其在HSC维持和分化中的作用。 （注：原文中“lodgement”疑似拼写错误，可能是“lodgment”，但按要求未做修改。）
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