Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran,Iran.
Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe St, Room 143, Baltimore, MD 21287,United States.
Infect Disord Drug Targets. 2021;21(7):e160921188928. doi: 10.2174/1871526520666201209145001.
Since December 2019, there has been an increasing number of patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) around the world. As of March 2020, the World Health Organization declared a global pandemic.
To our best knowledge, this is the first report of a patient with SARS-CoV-2 infection presenting with constrictive pericarditis, possibly from the COVID infection. She was presented after a week of fever, persistent dry cough, and diarrhea. She received a single dose of hydroxychloroquine 400 mg, Oseltamivir 75 mg every 12 hours, lopinavir/ritonavir (Kaletra) 400/100 mg every 12 hours, and levofloxacin 750 mg daily. After 24 hours, she was immediately transferred to the Intensive Care Unit (ICU) because of dyspnea and progressive respiratory failure with a drop of the O2 saturation to 70%.
After a week of progress, her respiratory condition deteriorated again. She was re-admitted to the ICU and she expired. She died due to constrictive pericarditis, most probably caused by SARS-CoV-2.
自 2019 年 12 月以来，全球感染严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的患者数量不断增加。截至 2020 年 3 月，世界卫生组织宣布全球大流行。
据我们所知，这是首例 SARS-CoV-2 感染引起缩窄性心包炎的患者报告，可能与 COVID 感染有关。她在发热一周后出现持续性干咳和腹泻后就诊。她接受了单次羟氯喹 400mg、奥司他韦 75mg 每 12 小时、洛匹那韦/利托那韦（克力芝）400/100mg 每 12 小时和左氧氟沙星 750mg 每日一次治疗。24 小时后，她因呼吸困难和进行性呼吸衰竭导致血氧饱和度降至 70%而立即转入重症监护病房（ICU）。
经过一周的进展，她的呼吸状况再次恶化。她再次被收入 ICU 并最终去世。她死于缩窄性心包炎，很可能是由 SARS-CoV-2 引起的。
