Proteomics and Translational Research Lab, Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University, Noida 201313, India.
CNS Neurol Disord Drug Targets. 2021;20(9):871-885. doi: 10.2174/1871527319666201209111006.
Poor nutritional effect of junk food induces injuries to the liver and the brain but still most of the developing nations survive on these diets to compensate for the fast-paced lifestyle. The aim of the study is to infer the protein-connections behind the liver-brain axis and identify the role of these proteins in causing neurodegenerative disorders.
Chronic consumption of fructose and fat-rich food works as a toxin in the body and has the ability to cause a negative metabolic shift. Recently a study was published in Annals of Internal Medicine (2019) citing the loss of vision and hearing in a 14-year-old boy whose diet was strictly restricted to fries and junk-food for almost a decade. This puts the entire body on insulin resistance and related co-morbidities and causes simultaneous damaging effects on the liver as well as the brain. This work provides insights into the liver-brain axis and explains how the liver is involved in brain related disorders.
In this study, transcriptomic data related to chronic eating of junk-food was analyzed and simultaneous damage that happens in the liver and the brain was assessed at the molecular level.
Transcriptomic study was taken from the GEO database and analysed to find out the genes dysregulated in both the liver and the brain during this metabolic stress. Cytoscapev3.7 was used to decipher the signalling between the liver and the brain. This connection between both is called as the liver-brain axis.
The results obtained from our study indicate the role of TUBB5-HYOU1-SDF2L1-DECR1- CDH1-EGFR-SKP2-SOD1-IRAK1-FOXO1 gene signature in the decline of concurrent liver and brain health. Dysregulated levels of these genes are linked to molecular processes like cellular senescence, hypoxia, glutathione synthesis, amino acid modification, increased nitrogen content, synthesis of BCAAs, cholesterol biosynthesis, steroid hormone signalling and VEGF pathway.
We strongly advocate that prolonged consumption of junk food is a major culprit in brain related disorders like Alzheimer's disease and propose that receptors for brain diseases lie outside the brain and aiming them for drug discovery and design may be beneficial in future clinical studies. This study also discusses the connection between NAFLD (non-alcoholic fatty liver disease) and sAD (sporadic Alzheimer's disease) owing to liver-brain axis.
垃圾食品的不良营养作用会导致肝脏和大脑受伤，但大多数发展中国家仍然依赖这些饮食来适应快节奏的生活方式。本研究旨在推断肝脑轴背后的蛋白质联系，并确定这些蛋白质在引起神经退行性疾病中的作用。
长期食用富含果糖和脂肪的食物会在体内产生毒素，并有能力引起负面的代谢转变。最近，《内科学年鉴》（2019 年）发表了一项研究，称一名 14 岁男孩的视力和听力丧失，他的饮食严格限制在薯条和垃圾食品近十年。这会使整个身体对胰岛素产生抗性，并导致相关的合并症，同时对肝脏和大脑造成同时的损害。这项工作深入了解了肝脑轴，并解释了肝脏如何参与与大脑相关的疾病。
在这项研究中，我们分析了与长期食用垃圾食品相关的转录组数据，并在分子水平上评估了这种代谢应激对肝脏和大脑的同时损害。
从 GEO 数据库中获取转录组学研究，并分析在这种代谢应激下肝脏和大脑中失调的基因。使用 Cytoscapev3.7 来解码肝脏和大脑之间的信号传递。这种肝脏和大脑之间的联系被称为肝脑轴。
我们的研究结果表明，TUBB5-HYOU1-SDF2L1-DECR1-CD H1-EGFR-SKP2-SOD1-IRAK1-FOXO1 基因特征在同时影响肝脏和大脑健康的下降中发挥作用。这些基因失调水平与细胞衰老、缺氧、谷胱甘肽合成、氨基酸修饰、氮含量增加、BCAAs 合成、胆固醇生物合成、类固醇激素信号和 VEGF 通路等分子过程有关。
我们强烈主张，长期食用垃圾食品是导致阿尔茨海默病等与大脑相关的疾病的主要罪魁祸首，并提出针对大脑疾病的受体位于大脑之外，针对它们进行药物发现和设计可能对未来的临床研究有益。本研究还讨论了由于肝脑轴，非酒精性脂肪性肝病（NAFLD）和散发性阿尔茨海默病（sAD）之间的联系。
