Department of Physiology and Biophysics and Center for Cardiovascular Research, Chicago, IL; and.
Division of Cardiology, Department of Medicine, University of Illinois at Chicago, College of Medicine, Chicago, IL.
J Cardiovasc Pharmacol. 2021 Mar 1;77(3):317-322. doi: 10.1097/FJC.0000000000000968.
A dominant mechanism of sudden cardiac death in the young is the progression of maladaptive responses to genes encoding proteins linked to hypertrophic cardiomyopathy. Most are mutant sarcomere proteins that trigger the progression by imposing a biophysical defect on the dynamics and levels of myofilament tension generation. We discuss approaches for personalized treatments that are indicated by recent advanced understanding of the progression.
导致年轻人心源性猝死的主要机制是对编码与肥厚型心肌病相关蛋白的基因产生的适应性反应失调的进展。大多数是突变的肌节蛋白，通过对肌丝张力产生的动力学和水平施加生物物理缺陷来引发进展。我们讨论了根据最近对进展的深入了解而表明的个性化治疗方法。
