Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, North Carolina, USA.
Can Vet J. 2020 Dec;61(12):1283-1289.
Cyclosporine is used to treat immune-mediated and allergic conditions and to prevent transplant rejection. To determine the prevalence of bacterial infections during cyclosporine therapy in dogs, 2 databases were searched and 14 articles reporting usable data were identified. In 828 dogs with atopic dermatitis receiving anti-allergic dosages of cyclosporine, the prevalence of bacterial infections was 11%; these occurred most often in the integument and urinary systems and not in multiple systems. In 95 dogs receiving cyclosporine at higher dosages for other conditions, the prevalence of bacterial infection was 17%, and these infections occurred most often in the gastrointestinal, urinary, and respiratory systems, often occurring at more than one body site. The prevalence of bacterial infections in atopic dogs treated with cyclosporine is low and occurs most often in the skin. When given for immunosuppression, the prevalence of bacterial infections is higher and can affect one or more body systems.
环孢素用于治疗免疫介导和过敏疾病，并预防移植排斥。为了确定犬中环孢素治疗期间细菌感染的流行情况，我们搜索了 2 个数据库，并确定了 14 篇报告可用数据的文章。在接受抗过敏剂量环孢素治疗特应性皮炎的 828 只狗中，细菌感染的患病率为 11%；这些感染最常发生在皮肤和泌尿系统，而不是多个系统。在 95 只因其他疾病接受高剂量环孢素治疗的狗中，细菌感染的患病率为 17%，这些感染最常发生在胃肠道、泌尿系统和呼吸系统，通常发生在一个以上的部位。接受环孢素治疗的特应性狗的细菌感染患病率较低，且最常发生在皮肤。当用于免疫抑制时，细菌感染的患病率更高，可影响一个或多个身体系统。
