Zhang Lingyun, Mao Huawu
Department of Laboratory Medicine, Zutangshan Hospital, Nanjing 211153, Jiangsu, People's Republic of China.
Department of Neurology, Taizhou Second People's Hospital, Taizhou 225500, Jiangsu, People's Republic of China.
Diabetes Metab Syndr Obes. 2020 Nov 30;13:4661-4667. doi: 10.2147/DMSO.S274232. eCollection 2020.
Previous studies have reported that diabetes mellitus (DM) is a risk factor for Alzheimer's disease (AD). Vascular cell adhesion molecule-1 (VCAM-1) plays an important role in the pathological process of atherosclerosis. The aim was to elucidate the relationship between serum VCAM-1 and early AD in DM patients.
Serum samples for VCAM-1 were tested in 208 DM patients. All included DM patients were followed up for a median of 36 months prospectively. The prognostic value of serum VCAM-1 for predicting AD events was analyzed by using Cox proportional hazard.
Serum VCAM-1 was independently associated with AD history after adjusting for related confounding factors in patients with DM at baseline by using the logistic regression analysis (OR=1.861; 95% CI, 1.435-2.539; =0.020). The Cox proportional hazard model suggested that VCAM-1 was a prognostic factor for AD events in the DM patients (HR=2.728; 95% CI, 1.785-5.439; <0.001). Stratified analysis showed that the significant association between AD event and serum VCAM-1 in DM patients was not affective by CVD history.
Our results showed that higher VCAM-1 levels were significantly related to a higher risk of AD events in DM patients. The serum biomarker might be beneficial to predict AD early. Serum VCAM-1 might be a good biochemical parameter for predicting AD in DM.
既往研究报道糖尿病（DM）是阿尔茨海默病（AD）的一个危险因素。血管细胞黏附分子-1（VCAM-1）在动脉粥样硬化的病理过程中起重要作用。本研究旨在阐明DM患者血清VCAM-1与早期AD之间的关系。
检测了208例DM患者的血清VCAM-1样本。所有纳入的DM患者进行了为期36个月的前瞻性随访。采用Cox比例风险模型分析血清VCAM-1对预测AD事件的预后价值。
通过逻辑回归分析对基线时DM患者的相关混杂因素进行校正后，血清VCAM-1与AD病史独立相关（OR=1.861；95%CI，1.435-2.539；P=0.020）。Cox比例风险模型表明，VCAM-1是DM患者AD事件的一个预后因素（HR=2.728；95%CI，1.785-5.439；P<0.001）。分层分析显示，DM患者中AD事件与血清VCAM-1之间的显著关联不受心血管疾病史的影响。
我们的结果表明，较高的VCAM-1水平与DM患者发生AD事件的较高风险显著相关。该血清生物标志物可能有助于早期预测AD。血清VCAM-1可能是预测DM患者AD的一个良好生化指标。
