去铁胺注射对兔复合移植物存活的影响。
The effect of deferoxamine injection on composite graft survival in rabbits.
作者信息
Ramli Rianto Noviady, Budi Agus Santoso, Rizaliyana Sitti, Fauzi Aditya Rifqi
机构信息
Plastic Reconstructive, and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia.
Department of Plastic Reconstructive, and Aesthetic Surgery, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo Hospital, Surabaya, Indonesia.
出版信息
Ann Med Surg (Lond). 2020 Nov 21;60:542-545. doi: 10.1016/j.amsu.2020.11.029. eCollection 2020 Dec.
BACKGROUND
Composite graft as a reconstructive therapy option has limitations in size so that it is easily necrotic. Deferoxamine administration has been associated with increased neo-vascularity in wounds. We aimed to compare the administration of deferoxamine and Platelet-Rich Plasma (PRP) injection in a composite graft in rabbits.
METHODS
Thirty New Zealand rabbits were divided into three groups; the control group, the deferoxamine group, and the PRP group. The composite graft with a diameter of 2 cm was taken and replanted after rotating it 180°. The mean graft viability and the mean number of capillaries were evaluated on day 7 (POD 7) by macroscopic and histological evaluation using Hematoxylin-Eosin staining.
RESULTS
While the mean number of capillaries was not significantly different in control, deferoxamine, and PRP groups ( = 0.21), the mean survival rate in the control, deferoxamine, and PRP groups reached a significant level with -value of 0.006 (66.6% 63.8% 99.6%, respectively).
CONCLUSIONS
Deferoxamine group had the highest number of capillaries, but had the lowest survival rate. In the PRP group, it had the lowest number of capillaries, but had the highest survival rate.
背景
复合移植物作为一种重建治疗选择，在尺寸上存在局限性，因此容易坏死。去铁胺的给药与伤口新生血管增加有关。我们旨在比较去铁胺和富血小板血浆（PRP）注射对兔复合移植物的影响。
方法
将30只新西兰兔分为三组；对照组、去铁胺组和PRP组。取直径为2 cm的复合移植物，旋转180°后重新植入。在术后第7天（POD 7），通过苏木精-伊红染色的宏观和组织学评估来评估移植物的平均存活率和平均毛细血管数量。
结果
虽然对照组、去铁胺组和PRP组的平均毛细血管数量无显著差异（P = 0.21），但对照组、去铁胺组和PRP组的平均存活率达到显著水平，P值为0.006（分别为66.6%、63.8%、99.6%）。
结论
去铁胺组的毛细血管数量最多，但存活率最低。在PRP组中，毛细血管数量最少，但存活率最高。
Zotero 插件