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由草药兴奋剂“巧茶”引起的药物性肝损伤

Drug-Induced Liver Injury Caused by "Khat," an Herbal Stimulant.

作者信息

Palacios Argueta Pedro, Attar Bashar, Sikavi Cameron, Alagiozian-Angelova Victoria, Mishra Satya

机构信息

Internal Medicine Department, Cook County Health, Chicago, IL.

Department of Gastroenterology and Hepatology, Cook County Health, Chicago, IL.

出版信息

ACG Case Rep J. 2020 Nov 23;7(11):e00480. doi: 10.14309/crj.0000000000000480. eCollection 2020 Nov.

DOI:10.14309/crj.0000000000000480
PMID:33299901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7721222/
Abstract

We describe a case of (Khat) drug-induced liver injury in a 28-year-old man from Yemen. The patient presented with jaundice, fatigue, and anorexia. Extensive workup, including liver biopsy, was performed. This is the first reported case in the United States without definite autoimmune hepatitis. Diagnosis requires high clinical suspicion and extensive workup. Increasing migration and differences in cultural practices lead to the need for an increased awareness of this type of cases, which is underreported.

摘要

我们描述了一例来自也门的28岁男性因恰特草药物导致肝损伤的病例。该患者出现黄疸、乏力和厌食症状。进行了包括肝活检在内的全面检查。这是美国首例无明确自身免疫性肝炎的报告病例。诊断需要高度的临床怀疑和全面检查。移民增加和文化习俗差异导致需要提高对这类报告不足病例的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f7/7721222/0a42fcdf2a28/ac9-7-e00480-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f7/7721222/3b4dbc925fd3/ac9-7-e00480-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f7/7721222/0a42fcdf2a28/ac9-7-e00480-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f7/7721222/3b4dbc925fd3/ac9-7-e00480-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f7/7721222/0a42fcdf2a28/ac9-7-e00480-g003.jpg

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本文引用的文献

1
Acute Liver Injury Associated with Khat Use in a 24-Year-Old Male.一名24岁男性因使用巧茶导致急性肝损伤
Case Reports Hepatol. 2018 Nov 21;2018:2816907. doi: 10.1155/2018/2816907. eCollection 2018.
2
Khat (Catha edulis Forsk) - And now there are three.阿拉伯茶（巧茶，Catha edulis Forsk）——现在有三种了。
Brain Res Bull. 2019 Feb;145:92-96. doi: 10.1016/j.brainresbull.2018.07.014. Epub 2018 Jul 27.
3
Unexplained chronic liver disease in Ethiopia: a cross-sectional study.埃塞俄比亚不明原因的慢性肝病：一项横断面研究。
草药和膳食补充剂引起的肝损伤：近期文献综述要点
World J Hepatol. 2021 Sep 27;13(9):1019-1041. doi: 10.4254/wjh.v13.i9.1019.
BMC Gastroenterol. 2018 Feb 13;18(1):27. doi: 10.1186/s12876-018-0755-5.
4
Khat chewing increases the risk for developing chronic liver disease: A hospital-based case-control study.嚼恰特草会增加慢性肝病的发病风险：一项基于医院的病例对照研究。
Hepatology. 2018 Jul;68(1):248-257. doi: 10.1002/hep.29809. Epub 2018 May 15.
5
Reversible khat-induced hepatitis: two case reports and review of the literature.可逆性巧茶所致肝炎：两例报告并文献复习
Frontline Gastroenterol. 2013 Oct;4(4):278-281. doi: 10.1136/flgastro-2013-100318. Epub 2013 May 10.
6
Hepatotoxicity Induced by "the 3Ks": Kava, Kratom and Khat.“3K”物质所致肝毒性：卡瓦、 kratom和巧茶
Int J Mol Sci. 2016 Apr 16;17(4):580. doi: 10.3390/ijms17040580.
7
"Natural Amphetamine" Khat: A Cultural Tradition or a Drug of Abuse?“天然安非他命”巧茶：一种文化传统还是滥用药物？
Int Rev Neurobiol. 2015;120:235-55. doi: 10.1016/bs.irn.2015.02.006. Epub 2015 Mar 9.
8
Khat (Catha Edulis) as a possible cause of autoimmune hepatitis.巧茶（恰特草）作为自身免疫性肝炎的一种可能病因。
World J Hepatol. 2014 Mar 27;6(3):150-4. doi: 10.4254/wjh.v6.i3.150.
9
Khat-associated hepatitis.恰特草相关性肝炎
Med J Aust. 2013 Oct 7;199(7):498-9. doi: 10.5694/mja13.10951.
10
Acute liver failure secondary to khat (Catha edulis)-induced necrotic hepatitis requiring liver transplantation: case report.因巧茶（恰特草）诱发坏死性肝炎继发急性肝衰竭需进行肝移植：病例报告
Transplant Proc. 2011 Nov;43(9):3493-5. doi: 10.1016/j.transproceed.2011.09.032.