β2-肾上腺素能受体在慢性阻塞性肺疾病中的作用。
Role of β2-adrenergic receptors in chronic obstructive pulmonary disease.
机构信息
Department of Respiratory Medicine, Beijing Friendship Hospital, Capital Medical University, 95 Yong An Road, Xicheng District, Beijing 100050, China.
Department of Respiratory Medicine, Beijing Friendship Hospital, Capital Medical University, 95 Yong An Road, Xicheng District, Beijing 100050, China.
出版信息
Life Sci. 2021 Jan 15;265:118864. doi: 10.1016/j.lfs.2020.118864. Epub 2020 Dec 7.
Beta-2 adrenergic receptors (β2-ARs) have important roles in the pathogenesis and treatment of chronic obstructive pulmonary disease (COPD). In recent years, progress has been made in the study of β2-ARs. Here, we introduce the basic concepts of β2-ARs, related pathways, as well as application of blockers/agonists of β2-ARs, and β2-AR autoantibodies in COPD. Drugs targeting the β2-AR are being developed rapidly, and we expect them to improve the symptoms and prognosis of COPD patients in the future.
β2 肾上腺素能受体（β2-ARs）在慢性阻塞性肺疾病（COPD）的发病机制和治疗中具有重要作用。近年来，β2-AR 的研究取得了进展。在这里，我们介绍β2-AR 的基本概念、相关途径以及β2-AR 阻滞剂/激动剂和β2-AR 自身抗体在 COPD 中的应用。针对β2-AR 的药物正在迅速开发，我们期望它们能改善 COPD 患者的症状和预后。
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