伊朗住院患儿中分泌型和Lewis 基因遗传变异的估计。
Estimation of genetic variation in the Secretor and Lewis genes in Iranian hospitalized children.
机构信息
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Transfus Clin Biol. 2021 Feb;28(1):11-15. doi: 10.1016/j.tracli.2020.12.001. Epub 2020 Dec 7.
BACKGROUND
The Secretor (FUT2) and lewis gene (FUT3) are in charge of the construction of histo-blood group antigens, which act as a receptor for some Pathogenes. This study aimed to estimate the prevalence of five significant single nucleotide polymorphisms (SNPs) in Iranian children.
METHODS
In this cross-sectional study, 102 blood samples collected from hospitalized children. The FUT2 gene region was amplified and sequenced to explore rs1047781 and rs601338, and the FUT3 gene region was amplified to explore rs28362459, rs812936, rs778986 SNPs.
RESULTS
In FUT2 gene, Se358,428 that produces Se phenotype with 63% (0.53 - 0.72) prevalence, was the most common genotype. For FUT3 gene Le59,202,314 with 80% prevalence was most common genotype (0.71 - 0.87).
CONCLUSION
This study genotyped Secretor and Lewis genes and designated SNPs' distinct distribution in Iran, and clarified at-risk groups for certain diseases.
背景
分泌型（FUT2）和 Lewis 基因（FUT3）负责构成组织血型抗原，这些抗原作为某些病原体的受体。本研究旨在评估伊朗儿童中五个重要单核苷酸多态性（SNP）的流行率。
方法
在这项横断面研究中，采集了 102 份住院儿童的血液样本。扩增并测序 FUT2 基因区域，以探索 rs1047781 和 rs601338，扩增 FUT3 基因区域以探索 rs28362459、rs812936、rs778986 SNP。
结果
在 FUT2 基因中，产生 Se 表型的 Se358,428 是最常见的基因型，其流行率为 63%（0.53-0.72）。对于 FUT3 基因 Le59,202,314，最常见的基因型是 80%（0.71-0.87）。
结论
本研究对分泌型和 Lewis 基因进行了基因分型，并确定了伊朗特定 SNP 的独特分布，明确了某些疾病的高危人群。
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