First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Int J Mol Sci. 2020 Dec 8;21(24):9335. doi: 10.3390/ijms21249335.
Salivary gland carcinomas (SGCs) represent a group of rare tumors, with complete surgical resection being the main treatment option. Therapeutic armory for cases of locally aggressive, recurrent, and/or metastatic SGCs, though, remains poor since they exhibit high rates of resistance to systematic therapy. Angiogenesis is considered one of the contemporary hallmarks of cancer and anti-angiogenic factors have already been approved for the treatment of several cancer types. This review aims to summarize, in a histotype-specific manner, the most current available data on the angiogenic factors implicated in SGC angiogenesis, in order to highlight the differences between the most common SGC histotypes and the factors that may have a potential role as therapeutic targets.
唾液腺癌（SGC）是一组罕见的肿瘤，完全手术切除是主要的治疗选择。然而，对于局部侵袭性、复发性和/或转移性 SGC 病例，治疗方法仍然很差，因为它们对系统治疗有很高的耐药性。血管生成被认为是癌症的当代标志之一，抗血管生成因子已经被批准用于治疗多种癌症类型。本综述旨在以组织类型特异性的方式总结目前关于 SGC 血管生成中涉及的血管生成因子的最新可用数据，以突出最常见的 SGC 组织类型之间的差异以及可能作为治疗靶点的因子。
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