唾液腺肿瘤形成与恶变相关因素的研究进展
A Review of Selected Factors of Salivary Gland Tumour Formation and Malignant Transformation.
机构信息
Department of Otorhinolaryngology and Oncological Laryngology in Zabrze, Medical University of Silesia, Katowice, Poland.
Department of Otorhinolaryngology, Faculty of Medicine, University of Rzeszow, Poland.
出版信息
Biomed Res Int. 2018 Aug 1;2018:2897827. doi: 10.1155/2018/2897827. eCollection 2018.
Abstract
Salivary gland tumours represent about 6% of head and neck neoplasms and about 0.5% of all malignancies in humans. Tumour growth and malignant transformation are complex processes involving various actions of molecules. Furthermore, some malignant salivary gland tumours are deemed to be caused by dedifferentiation or malignant transformation of benign tumours. The mechanisms of this transformation depend on a variety of different elements, such as cell cycle regulators, oncogenes, proteins, angiogenesis factors, and adipocytokines. The authors used PubMed, Medline, and Google websites to find and review the most significant papers related to malignant transformation in benign salivary gland tumours.
摘要
唾液腺肿瘤占头颈部肿瘤的 6%左右，占人类所有恶性肿瘤的 0.5%左右。肿瘤的生长和恶性转化是一个复杂的过程，涉及到分子的各种作用。此外，一些恶性唾液腺肿瘤被认为是良性肿瘤的去分化或恶性转化引起的。这种转化的机制取决于多种不同的因素，如细胞周期调节剂、癌基因、蛋白质、血管生成因子和脂肪细胞因子。作者使用 PubMed、Medline 和 Google 网站查找和回顾了与良性唾液腺肿瘤恶性转化相关的最重要的论文。
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