Hawsawi Yousef MohammedRabaa, Zailaie Samar Abdullah, Oyouni Atif Abdulwahab A, Alzahrani Othman Rashed, Alamer Osama Mohamed, Aljohani Saad Ali S
Saudi Human Genome Program-Jeddah Satellite Laboratory, Research Center, King Faisal Specialist Hospital and Research Center, MBC-J04, P.O. Box 40047, Jeddah, 21499, Kingdom of Saudi Arabia.
College of Medicine, Al-Faisal University, P.O. Box 50927, Riyadh, 11533, Saudi Arabia.
J Biol Res (Thessalon). 2020 Dec 10;27(1):20. doi: 10.1186/s40709-020-00128-z.
Prostate cancer (PC) is the most prevalent type of cancer in men worldwide. In Saudi Arabia, the rate of PC is increasing annually. The sex steroid hormones androgens and their receptors have critical roles in PC development and progression. Additionally, apoptosis-related proteins such as heat-shock proteins are vital molecules in PC development. Steroid hormone-deprivation therapies remain the essential treatment for patients with metastatic PCs; however, acquired resistance to hormone deprivation and the transition to PC androgen independence is a major health obstacle. In this review, we aim to detail the roles of androgens, androgen receptors and sex steroid hormones in inducing apoptosis in PC.
前列腺癌（PC）是全球男性中最常见的癌症类型。在沙特阿拉伯，PC的发病率逐年上升。性类固醇激素雄激素及其受体在PC的发生和发展中起着关键作用。此外，凋亡相关蛋白如热休克蛋白是PC发展中的重要分子。类固醇激素剥夺疗法仍然是转移性PC患者的主要治疗方法；然而，对激素剥夺的获得性耐药以及向PC雄激素非依赖性的转变是一个主要的健康障碍。在本综述中，我们旨在详细阐述雄激素、雄激素受体和性类固醇激素在诱导PC细胞凋亡中的作用。
