School of Psychology, University of La Laguna, La Laguna, Spain.
Departament of Neurology, N.S. La Candelaria University Hospital, S/C de Tenerife, Spain.
J Int Neuropsychol Soc. 2021 Aug;27(7):722-732. doi: 10.1017/S1355617720001216. Epub 2020 Dec 11.
Subjective cognitive decline (SCD) and mild cognitive impairment (MCI) in Parkinson's disease (PD) are considered as the risk factors for dementia (PDD). Posterior cortically based functions, such as visuospatial and visuoperceptual (VS-VP) processing, have been described as predictors of PDD. However, no investigations have focused on the qualitative analysis of the Judgment of Line Orientation Test (JLOT) and the Facial Recognition Test (FRT) in PD-SCD and PD-MCI. The aim of this work was to study the VS-VP errors in JLOT and FRT. Moreover, these variables are considered as predictors of PDD.
Forty-two PD patients and 19 controls were evaluated with a neuropsychological protocol. Patients were classified as PD-SCD and PD-MCI. Analyses of errors were conducted following the procedure described by Ska, Poissant, and Joanette (1990). Follow-up assessment was conducted to a mean of 7.5 years after the baseline.
PD-MCI patients showed a poor performance in JLOT and FRT total score and made a greater proportion of severe intraquadrant (QO2) and interquadrant errors (IQO). PD-SCD showed a poor performance in FRT and made mild errors in JLOT. PD-MCI and QO2/IQO errors were independent risk factors for PDD during the follow-up. Moreover, the combination of both PD-MCI diagnosis and QO2/IQO errors was associated with a greater risk.
PD-MCI patients presented a greater alteration in VS-VP processing observable by the presence of severe misjudgments. PD-SCD patients also showed mild difficulties in VS-SP functions. Finally, QO2/IQO errors in PD-MCI are a useful predictor of PDD, more than PD-MCI diagnosis alone.
帕金森病（PD）患者的主观认知下降（SCD）和轻度认知障碍（MCI）被认为是痴呆（PDD）的危险因素。后部皮质为主的功能，如视空间和视知觉（VS-VP）加工，已被描述为 PDD 的预测因子。然而，目前尚无研究关注 PD-SCD 和 PD-MCI 患者在判断线定向测验（JLOT）和面部识别测验（FRT）中的定性分析。本研究旨在研究 JLOT 和 FRT 中的 VS-VP 错误。此外，这些变量被认为是 PDD 的预测因子。
对 42 例 PD 患者和 19 例对照组进行神经心理学评估。患者分为 PD-SCD 和 PD-MCI。根据 Ska、Poissant 和 Joanette（1990）描述的程序对错误进行分析。在基线后平均 7.5 年进行随访评估。
PD-MCI 患者在 JLOT 和 FRT 总分方面表现较差，且在象限内（QO2）和象限间（IQO）错误中存在较大比例的严重错误。PD-SCD 在 FRT 中表现较差，在 JLOT 中出现轻度错误。PD-MCI 和 QO2/IQO 错误是随访期间 PDD 的独立危险因素。此外，PD-MCI 诊断和 QO2/IQO 错误的结合与更大的风险相关。
PD-MCI 患者的 VS-VP 处理存在较大改变，表现为严重判断错误。PD-SCD 患者的 VS-SP 功能也存在轻度困难。最后，PD-MCI 中的 QO2/IQO 错误是 PDD 的有用预测因子，比 PD-MCI 诊断本身更有意义。
