Newman Jonathan D, Bhatt Deepak L, Rajagopalan Sanjay, Balmes John R, Brauer Michael, Breysse Patrick N, Brown Alison G M, Carnethon Mercedes R, Cascio Wayne E, Collman Gwen W, Fine Lawrence J, Hansel Nadia N, Hernandez Adrian, Hochman Judith S, Jerrett Michael, Joubert Bonnie R, Kaufman Joel D, Malik Ali O, Mensah George A, Newby David E, Peel Jennifer L, Siegel Jeffrey, Siscovick David, Thompson Betsy L, Zhang Junfeng, Brook Robert D
Division of Cardiology and the Center for the Prevention of Cardiovascular Disease, New York University Grossman School of Medicine, New York, New York, USA.
Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, Massachusetts, USA. Electronic address: https://twitter.com/DLBhattMD.
J Am Coll Cardiol. 2020 Dec 15;76(24):2878-2894. doi: 10.1016/j.jacc.2020.10.020.
Fine particulate air pollution <2.5 μm in diameter (PM) is a major environmental threat to global public health. Multiple national and international medical and governmental organizations have recognized PM as a risk factor for cardiopulmonary diseases. A growing body of evidence indicates that several personal-level approaches that reduce exposures to PM can lead to improvements in health endpoints. Novel and forward-thinking strategies including randomized clinical trials are important to validate key aspects (e.g., feasibility, efficacy, health benefits, risks, burden, costs) of the various protective interventions, in particular among real-world susceptible and vulnerable populations. This paper summarizes the discussions and conclusions from an expert workshop, Reducing the Cardiopulmonary Impact of Particulate Matter Air Pollution in High Risk Populations, held on May 29 to 30, 2019, and convened by the National Institutes of Health, the U.S. Environmental Protection Agency, and the U.S. Centers for Disease Control and Prevention.
直径小于2.5微米的细颗粒物空气污染（PM）是对全球公众健康的主要环境威胁。多个国家和国际医学及政府组织已将PM认定为心肺疾病的一个风险因素。越来越多的证据表明，几种减少PM暴露的个人层面方法可使健康指标得到改善。包括随机临床试验在内的新颖且具有前瞻性的策略对于验证各种防护干预措施的关键方面（如可行性、有效性、健康益处、风险、负担、成本）很重要，尤其是在现实世界中的易感和脆弱人群中。本文总结了由美国国立卫生研究院、美国环境保护局和美国疾病控制与预防中心于2019年5月29日至30日举办的一次专家研讨会“降低高危人群中颗粒物空气污染对心肺的影响”的讨论内容和结论。
