革兰氏阴性皮肤和软组织感染。

Gram-Negative Skin and Soft Tissue Infections.

机构信息

Division of Infectious Diseases, Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon.

出版信息

Infect Dis Clin North Am. 2021 Mar;35(1):157-167. doi: 10.1016/j.idc.2020.10.008. Epub 2020 Dec 7.

DOI:10.1016/j.idc.2020.10.008

PMID:33303333

Abstract

Skin and soft tissue infections (SSTIs) frequently are encountered in clinical practice, and gram-negative bacilli (GNB) constitute an underrated portion of their etiology. The rate of GNB-causing SSTIs is increasing, especially with the rise in antimicrobial resistance. Although the diagnosis of SSTIs mostly is clinical, rapid diagnostic modalities can shorten the time to initiating proper therapy and improving outcomes. Novel antibiotics are active against GNB SSTIs and can be of great value in the management. This review provides an overview of the role of GNB in SSTIs and summarizes their epidemiology, risk factors, outcome, and clinical management.

摘要

皮肤和软组织感染（SSTIs）在临床实践中经常遇到，革兰氏阴性杆菌（GNB）构成其病因的低估部分。引起 GNB 的 SSTIs 的发生率正在增加，尤其是随着抗微生物药物耐药性的上升。虽然 SSTIs 的诊断主要是临床的，但快速诊断方法可以缩短开始适当治疗和改善结果的时间。新型抗生素对 GNB SSTIs 具有活性，在治疗中具有重要价值。本综述概述了 GNB 在 SSTIs 中的作用，并总结了它们的流行病学、危险因素、结果和临床管理。