Laboratory of Experimental Immunology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Sao Paulo, SP, Brazil.
Laboratory of Immunology and Bioinformatics, Department of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Federal University of Triangulo Mineiro, Uberaba, MG, Brazil.
Trends Parasitol. 2021 Apr;37(4):340-354. doi: 10.1016/j.pt.2020.11.004. Epub 2020 Dec 7.
From seminal publications in the early 1970s, the world learned that dendritic cells (DCs) are powerful and versatile antigen-presenting cells. It took a few years until the first studies expanded our understanding of the pivotal role of these immune 'soldiers' against ticks. Advances in biochemistry, molecular biology, and bioinformatics have shed light on the identification of key salivary molecules that modulate the biology of DCs in favor of tick parasitism. Here, we present a critical overview of the discoveries accumulated on the tick-host battlefield from a DC perspective. Moreover, the clinical significance of DC-targeted tick salivary components is discussed, not only as facilitators of the transmission of tick-borne pathogens or vaccine candidates, but also as potential immunobiologics to treat immune-mediated diseases.
从 20 世纪 70 年代初的开创性出版物开始，人们了解到树突状细胞 (DC) 是强大而多功能的抗原呈递细胞。直到几年后，第一批研究才扩展了我们对这些免疫“士兵”在对抗蜱虫方面的关键作用的理解。生物化学、分子生物学和生物信息学的进步揭示了关键唾液分子的鉴定，这些分子调节 DC 的生物学以有利于蜱虫寄生。在这里，我们从 DC 的角度对蜱虫-宿主战场上的发现进行了批判性的综述。此外，还讨论了针对 DC 的蜱唾液成分的临床意义，不仅作为蜱传病原体或疫苗候选物传播的促进剂，而且还作为治疗免疫介导性疾病的潜在免疫生物制剂。
