Artiach Gonzalo, Bäck Magnus
Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
Front Cell Dev Biol. 2020 Nov 12;8:584128. doi: 10.3389/fcell.2020.584128. eCollection 2020.
Inflammation is well-established in cardiovascular disease, including valvular heart disease. Inflammation is a key process in the fibrosis and calcification of the aortic valve leaflets, which ultimately clinically manifest as aortic valve stenosis characterized by valve dysfunction and cardiac obstruction. In the absence of pharmacological treatment, either surgical or transcatheter aortic valve replacement is currently the only available therapeutic strategy for patients with severe aortic valve stenosis. Omega-3 polyunsaturated fatty acids, which exert beneficial effects in several cardiovascular diseases, serve as the substrate for several bioactive lipid mediators that regulate inflammation. Recent findings point to the beneficial effects of omega-3 fatty acids in cardiac valves, being inversely associated with aortic valve calcification and contributing to the resolution of valvular inflammation by means of the pro-resolving mediator resolvin E1 and downstream signaling through its receptor ChemR23.
炎症在心血管疾病（包括心脏瓣膜病）中已得到充分证实。炎症是主动脉瓣叶纤维化和钙化的关键过程，最终在临床上表现为以瓣膜功能障碍和心脏梗阻为特征的主动脉瓣狭窄。在缺乏药物治疗的情况下，外科手术或经导管主动脉瓣置换术目前是重度主动脉瓣狭窄患者唯一可用的治疗策略。ω-3多不饱和脂肪酸在几种心血管疾病中发挥有益作用，是几种调节炎症的生物活性脂质介质的底物。最近的研究结果表明，ω-3脂肪酸对心脏瓣膜有益，与主动脉瓣钙化呈负相关，并通过促消退介质消退素E1及其通过受体ChemR23的下游信号传导，促进瓣膜炎症的消退。
