Balakumaran K, Jovanovic A, Fels P W, van Es G A, Bokslag M, Lubsen J, Hugenholtz P G
Thoraxcenter, University Hospital 'Dijkzigt', The Netherlands.
Eur Heart J. 1987 Dec;8 Suppl L:153-7. doi: 10.1093/eurheartj/8.suppl_l.153.
Alinidine, a drug which reduces heart rate without depressing myocardial function was compared against metoprolol, a beta-blocking drug, in the treatment of stable angina pectoris in a double-blind cross-over trial. It was found that both drugs reduced anginal attacks and nitroglycerine consumption to a comparable degree. Exercise tolerance did not appear to be improved by either drug yet chest pain at ergometry was postponed by both drugs. In the doses used metoprolol was more effective in restraining heart rate, both at rest and even more during exertion. Both drugs were well tolerated and side-effects were few. It seems probable that the optimal dose of alinidine was not used in this trial and that the dosage could have been higher.
在一项双盲交叉试验中，将阿利尼定（一种不降低心肌功能而降低心率的药物）与β受体阻滞剂美托洛尔用于稳定型心绞痛的治疗进行了比较。结果发现，两种药物在降低心绞痛发作次数和硝酸甘油用量方面程度相当。两种药物似乎均未改善运动耐量，但在运动试验时均延迟了胸痛发作。在所使用的剂量下，美托洛尔在静息时及运动时抑制心率方面更有效。两种药物耐受性良好，副作用较少。在该试验中似乎未使用阿利尼定的最佳剂量，其用量可能本可更高。
