Department of Obstetrics and Gynecology, Mohammad Bin Rashid University of Medicine and Health Sciences, Dubai, UAE.
Department of Obstetrics and Gynecology, Genesis Healthcare Center, Dubai, UAE.
Int J Gynaecol Obstet. 2021 Mar;152(3):291-298. doi: 10.1002/ijgo.13533. Epub 2020 Dec 27.
Pregnant women, their fetuses, and newborns are likely to represent a high-risk population during the current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Literature on the outcomes of COVID-19 infections during pregnancy is slowly building up. The aim of the present review was to gather evidence from relevant articles published in English from January to August 2020 in Medline and Google Scholar. The review revealed that pregnant women who become COVID-19-positive are usually either asymptomatic or mild-to-moderately symptomatic, similar to non-pregnant women. Pneumonia is one of the most common outcomes in pregnant women with COVID-19. However, it cannot be conclusively said that SARS-CoV-2 infection increases the risk of maternal, fetal, and neonatal complications. Pregnant women with COVID-19 with co-morbidities have increased risks of complications: there are regional variations in the rates of adverse outcomes reported. Though uncommon, the review shows that vertical transmission is possible. Additionally, the third trimester seems to be the most vulnerable period of infection. This aspect needs to be researched further to activate surveillance programs at the end of second trimester. Overall, it is necessary to monitor pregnant women before and after delivery, and their infants, during this pandemic.
孕妇、胎儿和新生儿在当前由严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)引起的 2019 年冠状病毒病(COVID-19)大流行期间可能代表高风险人群。关于 COVID-19 感染在妊娠期间的结局的文献正在逐渐增多。本综述的目的是从 2020 年 1 月至 8 月在 Medline 和 Google Scholar 上发表的英文相关文章中收集证据。综述结果表明,COVID-19 检测呈阳性的孕妇通常为无症状或轻度至中度症状,与非孕妇相似。肺炎是 COVID-19 孕妇中最常见的结局之一。然而,不能确定 SARS-CoV-2 感染会增加孕产妇、胎儿和新生儿并发症的风险。患有 COVID-19 合并症的孕妇有增加并发症的风险:报告的不良结局发生率存在地域差异。尽管罕见,但综述表明垂直传播是可能的。此外,妊娠晚期似乎是最易感染的时期。这一方面需要进一步研究,以便在妊娠中期结束时启动监测方案。总的来说,在这场大流行期间,有必要对孕妇及其婴儿进行分娩前后的监测。